Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats
dc.contributor.author | González Arceo, Maitane | |
dc.contributor.author | Aguirre López, Leixuri | |
dc.contributor.author | Macarulla Arenaza, María Teresa | |
dc.contributor.author | Gil Pitarch, Clàudia | |
dc.contributor.author | Martínez Chantar, María Luz | |
dc.contributor.author | Portillo Baquedano, María Puy | |
dc.contributor.author | Gómez Zorita, Saioa | |
dc.date.accessioned | 2024-04-08T13:02:24Z | |
dc.date.available | 2024-04-08T13:02:24Z | |
dc.date.issued | 2024-03-18 | |
dc.identifier.citation | Antioxidants 13(3) : (2024) // Article ID 369 | es_ES |
dc.identifier.issn | 2076-3921 | |
dc.identifier.uri | http://hdl.handle.net/10810/66542 | |
dc.description.abstract | Marine algae are valuable sources of bioactive compounds that have the potential to be used in the management of various pathologies. Despite the increasing prevalence of NAFLD, the absence of an approved effective pharmacological treatment with demonstrable effectiveness persists. In this context, the aim of the present study is to assess the effect of Gracilaria vermiculophylla red seaweed dietary supplementation on hepatic lipid accumulation, as well as on oxidative stress, inflammation and fibrosis- related markers on obese fa/fa Zucker rats fed with a standard diet, supplemented or not with 2.5% or 5% dehydrated Gracilaria vermiculophylla. After a six-week supplementation with the macroalga, no significant reduction in hepatic total lipid content or hepatic triglyceride content was observed. However, both doses were able to diminish hepatic NEFA concentration by reducing de novo lipogenesis and increasing mitochondrial biogenesis. Moreover, supplementation with the dose of 2.5% improved some oxidative stress and inflammation-related markers. Supplementation with the dose of 5% did not exert these clear beneficial effects. Thus, this study demonstrates that while Gracilaria vermiculophylla may not mitigate hepatic steatosis, it could exert protective effects on the liver by reducing NEFA content and enhancing oxidative stress and inflammation parameters. | es_ES |
dc.description.sponsorship | This study was supported by Instituto de Salud Carlos III (CIBERobn) under Grant CB12/03/30007, the Government of the Basque Country under Grants KK-2019-00031 and IT1482-22. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | alga | es_ES |
dc.subject | Gracilaria vermiculophylla | es_ES |
dc.subject | non-alcoholic fatty liver disease | es_ES |
dc.subject | oxidative stress | es_ES |
dc.subject | Zucker rat | es_ES |
dc.title | Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-03-27T13:16:27Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2076-3921/13/3/369 | es_ES |
dc.identifier.doi | 10.3390/antiox13030369 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).