dc.contributor.author | Bilbao Aldaiturriaga, Nerea | |
dc.contributor.author | Gutiérrez Camino, Ángela | |
dc.contributor.author | Martín Guerrero, Idoia | |
dc.contributor.author | Pombar Gómez, María | |
dc.contributor.author | Zalacain Díez, Marta | |
dc.contributor.author | Patiño García, Ana | |
dc.contributor.author | López López, Elixabet | |
dc.contributor.author | García-Orad Carles, África | |
dc.date.accessioned | 2024-04-15T13:48:57Z | |
dc.date.available | 2024-04-15T13:48:57Z | |
dc.date.issued | 2015-02-07 | |
dc.identifier.citation | Pediatric Blood & Cancer 62(5) : 766-769 (2015) | es_ES |
dc.identifier.issn | 1545-5017 | |
dc.identifier.issn | 1545-5009 | |
dc.identifier.uri | http://hdl.handle.net/10810/66676 | |
dc.description.abstract | Background
The possible associations between genetic variants and osteosarcoma risk have been analyzed without conclusive results. Those studies were focused mainly on genes of biologically plausible pathways. However, recently, another pathway has acquired relevance in cellular transformation and tumorigenesis, the microRNA (miRNA) processing pathway. Dysregulation of the expression levels of genes in this pathway has been described in cancer. Consequently, single nucleotide polymorphisms (SNPs) in genes that codify for proteins involved in the miRNA processing pathway may affect miRNAs, and therefore their target genes, which might be associated with cancer development and progression. The aim of this study was to evaluate whether SNPs in miRNA processing genes confer predisposition to osteosarcoma.
Procedure
We analyzed 72 SNPs in 21 miRNA processing genes in a total of 99 osteosarcoma patients and 387 controls.
Results
A total of three SNPs were associated with osteosarcoma susceptibility. Interestingly, these SNPs were located in miRNA processing genes (CNOT1, CNOT4 and SND1) which are part of the RISC complex. Among them, the association of rs11866002 in CNOT1 was nearly significant after Bonferroni correction.
Conclusions
This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1. | es_ES |
dc.description.sponsorship | This project was supported by the Spanish Thematic Network of Cooperative Investigation in Cancer RTICC (RD/12/0036/0036 and RD/12/0036/0060), Basque Government (IT661-13), and University of the Basque Country UPV/EHU (UFI11/35). AGC was supported by a predoctoral grant from the Basque Government (Programa de Formación de Personal Investigador no doctor, Departamento de Educación, Política Lingüística y Cultura del Gobierno Vasco). ELL was supported by a postdoctoral grant from the Basque Government (Programa Posdoctoral de Perfeccionamiento de Personal Investigador doctor, Departamento de Educación, Política Lingüística y Cultura del Gobierno Vasco). Technical support by SGIker (General Research Services, University of the Basque Country, UPV/EHU) is gratefully acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | microRNA processing pathway | es_ES |
dc.subject | genetic susceptibility | es_ES |
dc.subject | osteosarcoma | es_ES |
dc.title | Polymorphisms in miRNA processing genes and their role in osteosarcoma risk | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2015 Wiley Periodicals, Inc. | es_ES |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/pbc.25416 | es_ES |
dc.identifier.doi | 10.1002/pbc.25416 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |