BackAssociation between nutrient intake related to the one-carbon metabolism and colorectal cancer risk: a case–control study in the Basque Country
| dc.contributor.author | Martín Fernández de Labastida, Silvia | |
| dc.contributor.author | Alegría Lertxundi, Iker | |
| dc.contributor.author | Martínez de Pancorbo Gómez, María de los Angeles  | |
| dc.contributor.author | Arroyo Izaga, Marta | |
| dc.date.accessioned | 2024-04-15T15:20:03Z | |
| dc.date.available | 2024-04-15T15:20:03Z | |
| dc.date.issued | 2023 | |
| dc.identifier.citation | European Journal of Nutrition 62 : 3181-3191 (2023) | es_ES |
| dc.identifier.issn | 1436-6215 | |
| dc.identifier.issn | 1436-6207 | |
| dc.identifier.uri | http://hdl.handle.net/10810/66684 | |
| dc.description.abstract | Purpose Epidemiologic evidence for the association between methyl-donor nutrient intake and colorectal cancer (CRC) risk remains inconclusive. We aimed to examine the relationship between intake of vitamins of the B group, methionine, total choline and betaine and CRC risk, in a population from the CRC screening programme in the Basque Country. Design This observational study included 308 patients with CRC and 308 age- and sex-matched subjects as controls. During recruitment, dietary, anthropometric, lifestyle, socioeconomic, demographic, and health status information was collected. Conditional logistic regression was used to estimate the odds ratios (ORs) for CRC risk. Results The adjusted ORs for CRC risk decreased with higher intakes of choline and betaine (p < 0.05). After further adjustment for folate, high intake of choline and betaine remained associated with a reduced CRC risk (adjusted model for choline, OR third tertile vs first tertile = 0.45, 95% CI 0.26–0.80, p = 0.006; for betaine, OR third tertile vs first tertile = 0.27, 95% CI 0.16–0.47, p < 0.001). Regarding the other nutrients, our findings indicated a non-significant decrease in CRC risk with the high level of intake. Conclusions Our data suggest that choline and betaine intake influence CRC risk in the studied population. | es_ES |
| dc.description.sponsorship | Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Basque Government (Department of Health and Consumer Affairs, No. 2011111153; Saiotek programme, No. S-PE12UN058; BIOMICs Research Group, Microfluidics & BIOMICs Cluster of the University of the Basque Country UPV/EHU, No. IT1633-22). I.A.-L. was founded by a pre-doctoral grant from the Basque Government (PRE_2014_1_161, PRE_2015_2_0084, EP_2016_1_0098, EP_2016_1_0098, and PRE_2017_2_0006). | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Springer Nature | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.subject | colorectal cancer | es_ES |
| dc.subject | nutrients | es_ES |
| dc.subject | one-carbon metabolism | es_ES |
| dc.subject | diet | es_ES |
| dc.subject | protective factors | es_ES |
| dc.subject | case–control study | es_ES |
| dc.title | Association between nutrient intake related to the one-carbon metabolism and colorectal cancer risk: a case–control study in the Basque Country | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.rights.holder | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
| dc.rights.holder | Atribución 3.0 España | * |
| dc.relation.publisherversion | https://link.springer.com/article/10.1007/s00394-023-03229-2 | es_ES |
| dc.identifier.doi | 10.1007/s00394-023-03229-2 | |
| dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
| dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.