Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
dc.contributor.author | Milton Laskibar, Iñaki | |
dc.contributor.author | Marcos Zambrano, Laura Judith | |
dc.contributor.author | Gómez Zorita, Saioa | |
dc.contributor.author | Carrillo de Santa Pau, Enrique | |
dc.contributor.author | Fernández Quintela, Alfredo | |
dc.contributor.author | Martínez Hernández, José Alfredo | |
dc.contributor.author | Portillo Baquedano, María Puy | |
dc.date.accessioned | 2024-04-29T17:59:48Z | |
dc.date.available | 2024-04-29T17:59:48Z | |
dc.date.issued | 2022-04 | |
dc.identifier.citation | Gut Microbiome 3 : (2022) // Article ID e5 | es_ES |
dc.identifier.issn | 2632-2897 | |
dc.identifier.uri | http://hdl.handle.net/10810/66933 | |
dc.description.abstract | Consumption of high-energy-yielding diets, rich in fructose and lipids, is a factor contributing to the current increase in non-alcoholic fatty liver disease prevalence. Gut microbiota composition and short-chain fatty acids (SCFAs) production alterations derived from unhealthy diets are considered putative underlying mechanisms. This study aimed to determine relationships between changes in gut microbiota composition and SCFA levels by comparing rats featuring diet-induced steatohepatitis with control counterparts fed a standard diet. A high-fat high-fructose (HFHF) feeding induced higher body, liver and mesenteric adipose tissue weights, increased liver triglyceride content and serum transaminase, glucose, non-HDL-c and MCP-1 levels. Greater liver malondialdehyde levels and glutathione peroxidase activity were also observed after feeding the hypercaloric diet. Regarding gut microbiota composition, a lowered diversity and increased abundances of bacteria from the Clostridium sensu stricto 1, Blautia, Eubacterium coprostanoligenes group, Flavonifractor, and UBA1819 genera were found in rats featuring diet-induced steatohepatitis, as well as higher isobutyric, valeric and isovaleric acids concentrations. These results suggest that hepatic alterations produced by a hypercaloric HFHF diet may be related to changes in overall gut microbiota composition and abundance of specific bacteria. The shift in SCFA levels produced by this unbalanced diet cannot be discarded as potential mediators of the reported hepatic and metabolic alterations. | es_ES |
dc.description.sponsorship | I.M.-L. acknowledges financial support from the Juan de la Cierva Programme-Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2019-038925-I). L.J.M.-Z. has a Juan de la Cierva Grant (IJC2019-042188-I) from the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades. This research was funded by the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (grant number AGL-2015-65719-R MINECO/FEDER, UE), Instituto de Salud Carlos III CIBERobn (grant number CB12/03/30007) and University of the Basque Country (grant number GIU 18/173). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cambridge University Press | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/FJC2019-038925-I | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/IJC2019-042188-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | non-alcoholic steatohepatitis | es_ES |
dc.subject | rat | es_ES |
dc.subject | microbiota | es_ES |
dc.subject | high-fat high-fructose diet | es_ES |
dc.subject | short-chain fatty acids | es_ES |
dc.title | Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.cambridge.org/core/journals/gut-microbiome/article/involvement-of-microbiota-and-shortchain-fatty-acids-on-nonalcoholic-steatohepatitis-when-induced-by-feeding-a-hypercaloric-diet-rich-in-saturated-fat-and-fructose/9B9899B87CAC62F834BA48B7960DF526 | es_ES |
dc.identifier.doi | 10.1017/gmb.2022.2 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
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Except where otherwise noted, this item's license is described as © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed
under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted
re-use, distribution, and reproduction in any medium, provided the original work is properly cited