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Virulence genotype and phenotype of two clinical isolates of Arcobacter butzleri obtained from patients with different pathologies

dc.contributor.authorBaztarrika, Itsaso
dc.contributor.authorSalazar Sánchez, Adrián
dc.contributor.authorHernaez Crespo, Silvia
dc.contributor.authorLópez Mirones, José Israel
dc.contributor.authorCanut, Andrés
dc.contributor.authorAlonso Monsalve, Rodrigo
dc.contributor.authorMartínez Ballesteros, Ilargi ORCID
dc.contributor.authorMartínez Malax-Echevarría, Irati ORCID
dc.date.accessioned2024-05-02T18:02:51Z
dc.date.available2024-05-02T18:02:51Z
dc.date.issued2023-11
dc.identifier.citationArchives of Microbiology 205 : (2023) // Article ID 369es_ES
dc.identifier.issn1432-072X
dc.identifier.issn0302-8933
dc.identifier.urihttp://hdl.handle.net/10810/67336
dc.description.abstractThe surge in human arcobacteriosis has increased interest in determining the mechanisms involved in the pathogenesis of Arcobacter butzleri. Here, genomic analyses and in vitro Caco-2 infection, motility, urease and antimicrobial susceptibility testing (AST) assays were used to characterise the virulence and antimicrobial resistance (AMR) determinants of strains HC-1, isolated from a patient with travellers’ diarrhoea, and HC-2, isolated from another with pruritus. AMR determinants conferring resistance to tetracycline (tetO, present in both genomes) and to ampicillin and amoxicillin–clavulanic acid (bla3, present in HC-2) were identified. The same determinants associated with flagellum, chemotaxis, adhesion and invasion were detected in both, but HC-1 lacked eight flagellar genes. The urease cluster was only present in HC-1. Motility and urease tests confirmed the genetic differences between strains, but no genetic marker related to the inability of HC-2 to adhere and invade was identified. This inability could be conditioning the patient’s pathology.es_ES
dc.description.sponsorshipThis research was funded by the Eusko Jaurlaritza [Grant number PA20/03]; and the University of the Basque Country UPV/EHU [Grant number GIU21/021]. I.B and A.S.-S are recipients of Ph.D. fellowships from the Eusko Jaurlaritza and the University of the Basque Country UPV/EHU, respectively.es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectArcobacter butzleries_ES
dc.subjectcaco-2 infectiones_ES
dc.subjectcomparative genomicses_ES
dc.subjectantimicrobial resistancees_ES
dc.subjectvirulencees_ES
dc.titleVirulence genotype and phenotype of two clinical isolates of Arcobacter butzleri obtained from patients with different pathologieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00203-023-03709-3es_ES
dc.identifier.doi10.1007/s00203-023-03709-3
dc.departamentoesInmunología, microbiología y parasitologíaes_ES
dc.departamentoeuImmunologia, mikrobiologia eta parasitologiaes_ES


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© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.