Lipid fingerprint-based histology accurately classifies nevus, primary melanoma, and metastatic melanoma samples
dc.contributor.author | Huergo Baños, Cristina | |
dc.contributor.author | Velasco, Verónica | |
dc.contributor.author | Garate Yeregui, Jone | |
dc.contributor.author | Fernández Regueira, Roberto Antonio ![]() | |
dc.contributor.author | Martín Allende, Javier | |
dc.contributor.author | Zabalza Estévez, Ignacio | |
dc.contributor.author | Artola Igarza, Juan Luis | |
dc.contributor.author | Martí Laborda, Rosa María | |
dc.contributor.author | Asumendi Mallea, Aintzane ![]() | |
dc.contributor.author | Astigarraga, Egoitz | |
dc.contributor.author | Barreda Gómez, Gabriel | |
dc.contributor.author | Fresnedo Aranguren, María Olatz | |
dc.contributor.author | Ochoa Olascoaga, Begoña | |
dc.contributor.author | Boyano López, María Dolores ![]() | |
dc.contributor.author | Fernández González, José Andrés ![]() | |
dc.date.accessioned | 2024-05-02T18:03:11Z | |
dc.date.available | 2024-05-02T18:03:11Z | |
dc.date.issued | 2024-02 | |
dc.identifier.citation | International Journal of Cancer 154(4) : 712-722 (2024) | es_ES |
dc.identifier.issn | 1097-0215 | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.uri | http://hdl.handle.net/10810/67337 | |
dc.description.abstract | Probably, the most important factor for the survival of a melanoma patient is early detection and precise diagnosis. Although in most cases these tasks are readily carried out by pathologists and dermatologists, there are still difficult cases in which no consensus among experts is achieved. To deal with such cases, new methodologies are required. Following this motivation, we explore here the use of lipid imaging mass spectrometry as a complementary tool for the aid in the diagnosis. Thus, 53 samples (15 nevus, 24 primary melanomas, and 14 metastasis) were explored with the aid of a mass spectrometer, using negative polarity. The rich lipid fingerprint obtained from the samples allowed us to set up an artificial intelligence-based classification model that achieved 100% of specificity and precision both in training and validation data sets. A deeper analysis of the image data shows that the technique reports important information on the tumor microenvironment that may give invaluable insights in the prognosis of the lesion, with the correct interpretation. | es_ES |
dc.description.sponsorship | This project was supported by grants from the Basque Government (KK2017-041 and KK2020-00069 to JAF, BO and MDB and grant IT1491-22 to JAF), the UPV/EHU (GIU17/066 to MDB) and by MINECO (RTC-2015-3693-1). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RTC-2015-3693-1 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | biomarkers | es_ES |
dc.subject | lipid imaging mass spectrometry | es_ES |
dc.subject | melanoma | es_ES |
dc.subject | molecular histology | es_ES |
dc.title | Lipid fingerprint-based histology accurately classifies nevus, primary melanoma, and metastatic melanoma samples | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.34800 | es_ES |
dc.identifier.doi | 10.1002/ijc.34800 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoes | Lenguajes y sistemas informáticos | es_ES |
dc.departamentoes | Química física | es_ES |
dc.departamentoeu | Fisiologia | es_ES |
dc.departamentoeu | Hizkuntza eta sistema informatikoak | es_ES |
dc.departamentoeu | Kimika fisikoa | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.