Lab-in-a-Bead: Magnetic Janus Bead Probe for the Detection of Biomarkers in Blood
dc.contributor.author | Gunatilake, Udara Bimendra | |
dc.contributor.author | Caballé Ábalos, Adriana | |
dc.contributor.author | García Rey, Sandra | |
dc.contributor.author | Mercader Ruiz, Jon | |
dc.contributor.author | Basabe Desmonts, Lourdes | |
dc.contributor.author | Benito López, Fernando | |
dc.date.accessioned | 2024-05-02T18:04:06Z | |
dc.date.available | 2024-05-02T18:04:06Z | |
dc.date.issued | 2023-12 | |
dc.identifier.citation | Advanced Materials Interface 10(34) : (2023) // Article ID 2202459 | es_ES |
dc.identifier.issn | 2196-7350 | |
dc.identifier.issn | 2196-7350 | |
dc.identifier.uri | http://hdl.handle.net/10810/67340 | |
dc.description.abstract | Remotely handled miniaturized colorimetric sensor platforms with multiple functionalities are able to mimic conventional laboratory operations with reduced assets. The integration of a magnetic phase in a miniaturized hydrogel sensor system allows the manipulation of the sensor, under a magnetic field, in a programmable manner. However, dark color interferences from conventional magnetic phases (Fe3O4, Fe2O3, and Fe micro/nanoparticles) affect the signal readout, hindering the colorimetric response. Therefore, a novel Janus bead configuration is introduced and tested by the localized incorporation of ferromagnetic iron microparticles into a TiO2 nanotubes/alginate hydrogel bead biosystem, under an applied magnetic field. The so-called hydrogel Janus bead shows both, magnetic translocation and biosensing properties in the same bead. These beads are used for the direct colorimetric analysis of biomarkers in blood. The surface of the Janus bead prevents the biofouling of red blood cells, keeping the sensor surface clean for accurate optical colorimetric analysis. Moreover, the external magnetic manipulation of the bead permits precise control of the time and position of the bead in the sample. Therefore, multiple functionalities are presented by a single magnetic TiO2 nanotubes/alginate Janus bead such as actuation, low biofouling, and sensing, positioning this technology as a truly Lab-in-a-Bead System. | es_ES |
dc.description.sponsorship | The authors acknowledge the MaMi project, funded by the European Union's Horizon 2020 research and Innovation Programme under grant agreement no. 766007. The authors acknowledge funding support from the “Ministerio de Ciencia y Educación de España” under grant PID2020-120313GB-I00/AIE/10.13039/501100011033 y por FEDER una manera de hacer Europa, Gobierno Vasco Dpto. Educación for the consolidation of the research groups (IT1633-22) and Proyecto de Investigación Fundamental Colaborativa – Investigación Fundamental ELKARTEK: KK-2023/00070. Special thanks to (SGIker) of the University of the Basque Country (UPV/EHU) and Dr. Rafael Morales for SQUID characterization. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/766007 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-120313GB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | blood | es_ES |
dc.subject | colorimetric glucose | es_ES |
dc.subject | Janus beads | es_ES |
dc.subject | lab-in-a-bead | es_ES |
dc.subject | magnetic hydrogels | es_ES |
dc.subject | sensor scaffolds | es_ES |
dc.title | Lab-in-a-Bead: Magnetic Janus Bead Probe for the Detection of Biomarkers in Blood | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distributionand reproduction in any medium, provided the original work is properlycited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/admi.202202459 | es_ES |
dc.identifier.doi | 10.1002/admi.202202459 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoes | Zoología y biología celular animal | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distributionand reproduction in any medium, provided the original work is properlycited.