dc.contributor.author | López Domene, Rocío | |
dc.contributor.author | Kumar, Krishan | |
dc.contributor.author | Barcelón, José Eduardo | |
dc.contributor.author | Guedes, Gabriela | |
dc.contributor.author | Beloqui Elizazu, Ana | |
dc.contributor.author | López Cortajarena, Aitziber | |
dc.date.accessioned | 2024-05-06T16:35:28Z | |
dc.date.available | 2024-05-06T16:35:28Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nanoscale 15 : 16959-16966 (2023) | es_ES |
dc.identifier.issn | 2040-3364 | |
dc.identifier.issn | 2040-3372 | |
dc.identifier.uri | http://hdl.handle.net/10810/67538 | |
dc.description.abstract | Metalloenzymes represent exemplary systems in which an organic scaffold combines with a functional inorganic entity, resulting in excellent redox catalysts. Inspired by these natural hybrid biomolecules, biomolecular templates have garnered significant attention for the controlled synthesis of inorganic nanostructures. These nanostructures ultimately benefit from the protection and colloidal stabilization provided by the biomacromolecule. In this study, we have employed this strategy to prepare nanozymes with redox capabilities, utilizing the versatile catalytic profile of Pt-loaded nanomaterials. Thus, we have investigated protein-templated Pt-based nanoclusters of different sizes and compositions, which exhibit remarkable oxidase, catalase, and reductase-like activities. The interplay between the composition and catalytic activity highlighted the size of the nanocluster as the most prominent factor in determining the performance of the nanozymes. Additionally, we have demonstrated the use of protein-templated nanozymes as potential co-catalysts in combination with enzymes for coupled reactions, under both sequential and concurrent one-pot conditions. This study provides valuable insights into nanozyme design and its wide range of applications in the design of complex catalytic systems. | es_ES |
dc.description.sponsorship | A. L. C. acknowledges support by the Agencia Estatal de Investigación Grant PID2019-111649RB-I00 and PID2022-137977OB-100 funded by MCIN/AEI/10.13039/501100011033 and Grant PDC2021-120957-I00 funded by MCIN/AEI/10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”. This work was performed under the Maria de Maeztu Units of Excellence Program from Q5 the Spanish State Research Agency grant no. MDM-2017-0720. A. B. gratefully acknowledges the financial support from the Spanish Research Agency (AEI) for the financial support (PID2022-142128NB-I00 funded by MCIN/AEI/10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”; RYC2018-025923-I from RyC program – MCIN/AEI/10.13039/501100011033 and FSE “invierte en tu futuro”), BBVA Foundation – IN[21]_CBB_QUI_0086, and UPV/EHU – GIU21-033. K.K. thanks JdC Grant FJC2021-047607-I funded by MCIN/AEI/ 10.13039/501100011033. We thank Fernando López-Gallego for support with the oxygen consumption measurements. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | RSC | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-111649RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2022-137977OB-100 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PDC2021-120957-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/MDM-2017-0720 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2022-142128NB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RYC2018-025923-I | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/FJC2021-047607-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.title | Nanozymes with versatile redox capabilities inspired in metalloenzymes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Royal Society of Chemistry 2023. This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlehtml/2023/nr/d3nr03443g | es_ES |
dc.identifier.doi | 10.1039/D3NR03443G | |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |