Physicochemical Characterization and In Vitro Activity of Poly(ε-Caprolactone)/Mycophenolic Acid Amorphous Solid Dispersions
dc.contributor.author | Sánchez Aguinagalde, Oroitz | |
dc.contributor.author | Sánchez Rexach, Eva | |
dc.contributor.author | Polo Arroyabe, Yurena | |
dc.contributor.author | Larrañaga Espartero, Aitor ![]() | |
dc.contributor.author | Lejardi Meabebasterretxea, Ainhoa | |
dc.contributor.author | Meaurio Arrate, Emiliano ![]() | |
dc.contributor.author | Sarasua Oiz, José Ramón ![]() | |
dc.date.accessioned | 2024-05-08T14:55:02Z | |
dc.date.available | 2024-05-08T14:55:02Z | |
dc.date.issued | 2024-04-13 | |
dc.identifier.citation | Polymers 16(8) : (2024) // Article ID 1088 | es_ES |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | http://hdl.handle.net/10810/67734 | |
dc.description.abstract | The obtention of amorphous solid dispersions (ASDs) of mycophenolic acid (MPA) in poly(ε-caprolactone) (PCL) is reported in this paper. An improvement in the bioavailability of the drug is possible thanks to the favorable specific interactions occurring in this system. Differential scanning calorimetry (DSC) was used to investigate the miscibility of PCL/MPA blends, measuring glass transition temperature (Tg) and analyzing melting point depression to obtain a negative interaction parameter, which indicates the development of favorable inter-association interactions. Fourier transform infrared spectroscopy (FTIR) was used to analyze the specific interaction occurring in the blends. Drug release measurements showed that at least 70% of the drug was released by the third day in vitro in all compositions. Finally, preliminary in vitro cell culture experiments showed a decreased number of cancerous cells over the scaffolds containing MPA, presumably arising from the anti-cancer activity attributable to MPA. | es_ES |
dc.description.sponsorship | This research was funded by Spanish Ministry of Science and Innovation MICINN (PID2019-106236GB-I00) and the Basque Government Department of Education, Culture and Language Policy (IT1766-22). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-106236GB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | poly(ε-caprolactone) (PCL) | es_ES |
dc.subject | mycophenolic acid (MPA) | es_ES |
dc.subject | amorphous solid dispersions (ASDs) | es_ES |
dc.subject | miscibility | es_ES |
dc.subject | interactions | es_ES |
dc.subject | drug release | es_ES |
dc.subject | cancer treatment | es_ES |
dc.title | Physicochemical Characterization and In Vitro Activity of Poly(ε-Caprolactone)/Mycophenolic Acid Amorphous Solid Dispersions | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-04-27T14:05:59Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/16/8/1088 | es_ES |
dc.identifier.doi | 10.3390/polym16081088 | |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).