Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer’s Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms
dc.contributor.author | Dakterzada, Farida | |
dc.contributor.author | Cipriani, Raffaela | |
dc.contributor.author | López Ortega, Ricard | |
dc.contributor.author | Arias, Alfonso | |
dc.contributor.author | Riba Llena, Iolanda | |
dc.contributor.author | Ruiz Julián, María | |
dc.contributor.author | Huerto, Raquel | |
dc.contributor.author | Tahan, Nuria | |
dc.contributor.author | Matute Almau, Carlos José | |
dc.contributor.author | Capetillo González de Zarate, Estíbaliz | |
dc.contributor.author | Piñol Ripoll, Gerard | |
dc.date.accessioned | 2024-05-14T16:30:23Z | |
dc.date.available | 2024-05-14T16:30:23Z | |
dc.date.issued | 2024-04-23 | |
dc.identifier.citation | International Journal of Molecular Sciences 25(9) : (2024) // Article ID 4594 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/67941 | |
dc.description.abstract | We compared the clinical and analytical performance of Alzheimer’s disease (AD) plasma biomarkers measured using the single-molecule array (Simoa) and Lumipulse platforms. We quantified the plasma levels of amyloid beta 42 (Aβ42), Aβ40, phosphorylated tau (Ptau181), and total tau biomarkers in 81 patients with mild cognitive impairment (MCI), 30 with AD, and 16 with non-AD dementia. We found a strong correlation between the Simoa and Lumipulse methods. Concerning the clinical diagnosis, Simoa Ptau181/Aβ42 (AUC 0.739, 95% CI 0.592–0.887) and Lumipulse Aβ42 and Ptau181/Aβ42 (AUC 0.735, 95% CI 0.589–0.882 and AUC 0.733, 95% CI 0.567–0.900) had the highest discriminating power. However, their power was significantly lower than that of CSF Aβ42/Aβ40, as measured by Lumipulse (AUC 0.879, 95% CI 0.766–0.992). Simoa Ptau181 and Lumipulse Ptau181/Aβ42 were the markers most consistent with the CSF Aβ42/Aβ40 status (AUC 0.801, 95% CI 0.712–0.890 vs. AUC 0.870, 95% CI 0.806–0.934, respectively) at the ≥2.127 and ≥0.084 cut-offs, respectively. The performance of the Simoa and Lumipulse plasma AD assays is weaker than that of CSF AD biomarkers. At present, the analysed AD plasma biomarkers may be useful for screening to reduce the number of lumbar punctures in the clinical setting. | es_ES |
dc.description.sponsorship | This work was supported by grants from BIOEF (Convocatoria de Ayudas a la Investigación en Alzheimer de la Fundación Vasca de Innovación e Investigación Sanitarias) (#BIO22/ALZ/014, #BIO22/ALZ/015). GPR received funding from Diputació de Lleida (PP10605-PIRS2021) and Instituto de Salud Carlos III and was cofunded by the European Union (ERDF/ESF, “Investing in your future” and “A way to build Europe”) (PI22/01687). IRBLleida is a CERCA Program of the Government of Catalonia. FD is an IRBLleida IREP-2023 postdoctoral Fellow. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | Alzheimer’s disease | es_ES |
dc.subject | biomarker | es_ES |
dc.subject | plasma | es_ES |
dc.subject | Simoa | es_ES |
dc.subject | Lumipulse | es_ES |
dc.subject | cerebrospinal fluid | es_ES |
dc.subject | cut-off | es_ES |
dc.title | Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer’s Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-05-10T13:18:19Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/25/9/4594 | es_ES |
dc.identifier.doi | 10.3390/ijms25094594 | |
dc.departamentoes | Neurociencias | |
dc.departamentoeu | Neurozientziak |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).