Systemic cellular migration: The forces driving the directed locomotion movement of cells
dc.contributor.author | Martínez de la Fuente Martínez, Ildefonso Abel | |
dc.contributor.author | Carrasco Pujante, José | |
dc.contributor.author | Camino Pontes, Borja | |
dc.contributor.author | Fedetz, María | |
dc.contributor.author | Bringas Roldán, Carlos | |
dc.contributor.author | Pérez Samartín, Alberto Luis ![]() | |
dc.contributor.author | Pérez-Yarza Pérez-Irezabal, Gorka ![]() | |
dc.contributor.author | López Fernández de Villaverde, José Ignacio ![]() | |
dc.contributor.author | Malaina Celada, Iker ![]() | |
dc.contributor.author | Cortés, Jesús M. | |
dc.date.accessioned | 2024-05-20T13:43:46Z | |
dc.date.available | 2024-05-20T13:43:46Z | |
dc.date.issued | 2024-04 | |
dc.identifier.citation | PNAS Nexus 3(5) : (2024) // Article ID e171 | es_ES |
dc.identifier.issn | 2752-6542 | |
dc.identifier.uri | http://hdl.handle.net/10810/68043 | |
dc.description.abstract | Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements remains an unresolved question. Here, we have addressed the systemic processes driving the directed locomotion of cells. Specifically, we have performed an exhaustive study analyzing the trajectories of 700 individual cells belonging to three different species (Amoeba proteus, Metamoeba leningradensis, and Amoeba borokensis) in four different scenarios: in absence of stimuli, under an electric field (galvanotaxis), in a chemotactic gradient (chemotaxis), and under simultaneous galvanotactic and chemotactic stimuli. All movements were analyzed using advanced quantitative tools. The results show that the trajectories are mainly characterized by coherent integrative responses that operate at the global cellular scale. These systemic migratory movements depend on the cooperative nonlinear interaction of most, if not all, molecular components of cells. | es_ES |
dc.description.sponsorship | This work was supported by grant US21/27 from the University of Basque Country (UPV/EHU) and Basque Center of Applied Mathematics. In addition, this work was supported by Basque Government funding, grant IT456-22. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | cellular migration | es_ES |
dc.subject | systemic behavior | es_ES |
dc.subject | self-organization | es_ES |
dc.subject | quantitative analysis | es_ES |
dc.subject | amoebae | es_ES |
dc.title | Systemic cellular migration: The forces driving the directed locomotion movement of cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024, © The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences. This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://academic.oup.com/pnasnexus/article/3/5/pgae171/7655426 | es_ES |
dc.identifier.doi | 10.1093/pnasnexus/pgae171 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Matemáticas | es_ES |
dc.departamentoeu | Matematika | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2024, © The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.
This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.