dc.contributor.author | Arzuaga Mendez, Javier | |
dc.contributor.author | López Santillán, María | |
dc.contributor.author | García Ruiz, Juan Carlos | |
dc.contributor.author | López López, Elixabet | |
dc.contributor.author | Martín Guerrero, Idoia | |
dc.date.accessioned | 2024-05-22T14:41:14Z | |
dc.date.available | 2024-05-22T14:41:14Z | |
dc.date.issued | 2021-03 | |
dc.identifier.citation | Critical Reviews in Oncology/Hematology 159 : (2021) // Article ID 103247 | es_ES |
dc.identifier.issn | 1879-0461 | |
dc.identifier.issn | 1040-8428 | |
dc.identifier.uri | http://hdl.handle.net/10810/68098 | |
dc.description.abstract | Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma and usually presents as an indolent disease. However, some patients present poor outcomes, and FL can transform into more aggressive lymphomas, such as Diffuse Large B cell lymphoma (DLBCL). MicroRNAs (miRNA) are small RNA molecules that participate in posttranscriptional regulation of gene expression, that are emerging biomarkers in cancer. In this systematic review, we included studies evaluating miRNA expression in tumor tissue as diagnosis, transformation or prognosis biomarkers in FL. We identified several miRNAs, which could be diagnostic biomarkers in FL: miR-155-5p and miR-9-3p as miRNAs of potential utility for diagnosis of FL, and miR-150 and miR-17-92 cluster for differential diagnosis between FL and DLBCL. Prognosis and transformation prediction have not been studied in enough depth to draw solid conclusions. Further research is needed to exploit the potential of this field. | es_ES |
dc.description.sponsorship | This study was funded by the Basque Government (IT989-16 and BIO15/CA/022/BC). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | follicular lymphoma | es_ES |
dc.subject | microRNA | es_ES |
dc.subject | diagnosis | es_ES |
dc.subject | tansformation | es_ES |
dc.subject | prognosis | es_ES |
dc.title | Systematic review of the potential of MicroRNAs in the management of patients with follicular lymphoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1040842821000354 | es_ES |
dc.identifier.doi | 10.1016/j.critrevonc.2021.103247 | |
dc.departamentoes | Bioquímica y biología molecular | es_ES |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Biokimika eta biologia molekularra | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |