dc.contributor.author | Esporrín Ubieto, David | |
dc.contributor.author | Sonzogni, Ana | |
dc.contributor.author | Fernández San Martín, Mercedes | |
dc.contributor.author | Acera Osa, Arantxa | |
dc.contributor.author | Matxinandiarena Almandoz, Eider | |
dc.contributor.author | Cadavid Vargas, Juan Fernando | |
dc.contributor.author | Calafel Martínez, Miren Itxaso | |
dc.contributor.author | Schmarsow, Ruth N. | |
dc.contributor.author | Müller Sánchez, Alejandro Jesús | |
dc.contributor.author | Larrañaga Espartero, Aitor | |
dc.contributor.author | Calderón, Marcelo | |
dc.date.accessioned | 2024-05-24T13:02:15Z | |
dc.date.available | 2024-05-24T13:02:15Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Journal of Materials Chemistry B 11(38) : 9276-9289 (2023) | es_ES |
dc.identifier.issn | 2050-750X | |
dc.identifier.issn | 2050-7518 | |
dc.identifier.uri | http://hdl.handle.net/10810/68152 | |
dc.description.abstract | Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to clinical applications. Moreover, the reversible nature of their physical cross-links allows hydrogels to dissolve in the presence of external stimuli. Particularly, their high degree of hydration, high molecular weight, and superior flexibility of the polymer chains facilitate their interaction with complex biological barriers (e.g., mucus layer), making them ideal candidates for mucosal drug delivery. However, fine-tuning the composition of the hydrogel formulations is of great importance to optimize the performance of the medical device and its therapeutic cargo. Herein, we investigated the influence of different Eudragits® on the properties of hydrogels based on polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), which were originally proposed as ocular inserts in previous reports. Our research aims to determine the effects that including different Eudragits® have on the structure and protein ocular delivery ability of various hydrogel formulations. Properties such as matrix stability, protein encapsulation, release kinetics, mucoadhesion, and biocompatibility have been analyzed in detail. Our study represents a guideline of the features that Eudragits® have to exhibit to endow hydrogels with good adhesion to the eye's conjunctiva, biocompatibility, and structural strength to cope with the ocular biointerface and allow sustained protein release. This work has important implications for the design of new hydrogel materials containing Eudragits® in their composition, particularly in mucosal drug delivery. | es_ES |
dc.description.sponsorship | This research was funded by the Basque Government through
the ELKARTEK program (KK-2019(00086), Salud cara´cter estra-
te´gico (2021333047), the University of the Basque Country
(projects COLLAB22/05 and GIU21/033), and IKERBASQUE-
Basque Foundation for Science. We also gratefully acknowledge
support from the Basque Government through Grant IT1309-19
and R+D+i project PID2020-113045GB-C21 funded by MCIN/AEI/
10.13039/501100011033/. A Sonzogni acknowledges financial
support from CONICET, Universidad Nacional del Litoral, and
the European Union Commission through RISE Horizon 2020,
project 823989 IONBIKE. A Larran˜aga is thankful for funds from
the Basque Government, Department of Education (IT-1766-22). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | RSC | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-113045GB-C21 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.title | The role of Eudragit® as a component of hydrogel formulations for medical devices | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Royal Society of Chemistry 2023. This article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2023/tb/d3tb01579c | es_ES |
dc.identifier.doi | 10.1039/d3tb01579c | |
dc.departamentoes | Polímeros y Materiales Avanzados: Física, Química y Tecnología | es_ES |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | es_ES |
dc.departamentoeu | Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia | es_ES |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |