dc.contributor.author | Ruiz Alonso, Sandra | |
dc.contributor.author | Lafuente Merchán, Markel | |
dc.contributor.author | Ciriza Astrain, Jesús | |
dc.contributor.author | Sáenz del Burgo Martínez, Laura ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Pedraz Muñoz, José Luis ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.date.accessioned | 2024-05-27T15:10:51Z | |
dc.date.available | 2024-05-27T15:10:51Z | |
dc.date.issued | 2021-05 | |
dc.identifier.citation | Journal of Controlled Release 333 : 448-486 (2021) | es_ES |
dc.identifier.issn | 0168-3659 | |
dc.identifier.issn | 1873-4995 | |
dc.identifier.uri | http://hdl.handle.net/10810/68191 | |
dc.description.abstract | Tendon injuries are a global health problem that affects millions of people annually. The properties of tendons make their natural rehabilitation a very complex and long-lasting process. Thanks to the development of the fields of biomaterials, bioengineering and cell biology, a new discipline has emerged, tissue engineering. Within this discipline, diverse approaches have been proposed. The obtained results turn out to be promising, as increasingly more complex and natural tendon-like structures are obtained. In this review, the nature of the tendon and the conventional treatments that have been applied so far are underlined. Then, a comparison between the different tendon tissue engineering approaches that have been proposed to date is made, focusing on each of the elements necessary to obtain the structures that allow adequate regeneration of the tendon: growth factors, cells, scaffolds and techniques for scaffold development. The analysis of all these aspects allows understanding, in a global way, the effect that each element used in the regeneration of the tendon has and, thus, clarify the possible future approaches by making new combinations of materials, designs, cells and bioactive molecules to achieve a personalized regeneration of a functional tendon. | es_ES |
dc.description.sponsorship | Author thanks the Basque Government for granted fellowship to S. Ruiz-Alonso (PRE_2020_2_0143). This study was financially supported by the Basque Country Government (IT907-16) and the University of the Basque Country UPV/EHU-Fundación VITAL Fundazioa (VITAL20/25). Authors also wish to thank the intellectual and technical assistance from the ICTS “NANBIOSIS”, more specifically by the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) at the University of Basque Country (UPV/EHU). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | tendon regeneration | es_ES |
dc.subject | tissue engineering | es_ES |
dc.subject | scaffolds | es_ES |
dc.subject | growth factor | es_ES |
dc.subject | scaffold development techniques | es_ES |
dc.subject | 3D printing | es_ES |
dc.title | Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0168365921001516 | es_ES |
dc.identifier.doi | 10.1016/j.jconrel.2021.03.040 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |