dc.contributor.author | Vallinoja, Jaakko | |
dc.contributor.author | Nurmi, Timo | |
dc.contributor.author | Jaatela, Julia | |
dc.contributor.author | Wens, Vincent | |
dc.contributor.author | Bourguignon, Mathieu | |
dc.contributor.author | Mäenpäa, Helena | |
dc.contributor.author | Piitulainen, Harri | |
dc.date.accessioned | 2024-06-03T15:25:47Z | |
dc.date.available | 2024-06-03T15:25:47Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Vallinoja, J., Nurmi, T., Jaatela, J., Wens, V., Bourguignon, M., Mäenpää, H., & Piitulainen, H. (2024). Functional connectivity of sensorimotor network is enhanced in spastic diplegic cerebral palsy: A multimodal study using fMRI and MEG. Clinical Neurophysiology, 157, 4-14. Doi:10.1016/j.clinph.2023.10.014 | es_ES |
dc.identifier.citation | Clinical Neurophysiology | |
dc.identifier.issn | 1388-2457 | |
dc.identifier.uri | http://hdl.handle.net/10810/68321 | |
dc.description | Available online 7 November 2023 | es_ES |
dc.description.abstract | Objective: To assess the effects to functional connectivity (FC) caused by lesions related to spastic diplegic cerebral palsy (CP) in children and adolescents using multiple imaging modalities. Methods: We used resting state magnetoencephalography (MEG) envelope signals in alpha, beta and gamma ranges and resting state functional magnetic resonance imaging (fMRI) signals to quantify FC between selected sensorimotor regions of interest (ROIs) in 11 adolescents with spastic diplegic cerebral palsy and 24 typically developing controls. Motor performance of the hands was quantified with gross motor, fine motor and kinesthesia tests. Results: In fMRI, participants with CP showed enhanced FC within posterior parietal regions; in MEG, they showed enhanced interhemispheric FC between sensorimotor regions and posterior parietal regions both in alpha and lower beta bands. There was a correlation between the kinesthesia score and frontoparietal connectivity in the control population. Conclusions: CP is associated with enhanced FC in sensorimotor network. This difference is not correlated with hand coordination performance. The effect of the lesion is likely not fully captured by temporal correlation of ROI signals. Significance: Brain lesions can show as increased temporal correlation of activity between remote brain areas. We suggest this effect is likely separate from typical physiological correlates of functional connectivity. | es_ES |
dc.description.sponsorship | This study has been supported by the Academy of Finland ‘‘Brain changes across the life-span” profiling funding to University of Jyväskylä. HP was supported by Academy of Finland (grants #296240, #326988, #307250 and #327288) and Jane and Aatos Erkko Foundation. MEG research at the HUB–Hôpital Erasme is f inancially supported by the Fonds Erasme (Research Convention ‘‘Les Voies du Savoir”, Brussels, Belgium). MB was supported by the Fonds de la Recherche Scientifique (F.R.S.-FNRS, Brussels, Belgium; grant MIS F.4504.21). Wethank technical support from Helge Kainulainen in building someofthe measurement equipmentin Aalto NeuroImaging, Aalto University, Espoo, Finland. We also acknowledge the computational resources provided by the Aalto Science-IT project. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ELSEVIER | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Functional connectivity | es_ES |
dc.subject | Cerebral palsy | es_ES |
dc.subject | MEG | es_ES |
dc.subject | fMRI | es_ES |
dc.title | Functional connectivity of sensorimotor network is enhanced in spastic diplegic cerebral palsy: A multimodal study using fMRI and MEG | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/journal/clinical-neurophysiology | es_ES |
dc.identifier.doi | 10.1016/j.clinph.2023.10.014 | |