Systemic Tumors Can Cause Molecular Changes in the Hippocampus That May Have an Impact on Behavior after Chronic Social Stress
dc.contributor.author | Goñi Balentziaga, Olatz | |
dc.contributor.author | Díez Solinska, Alina | |
dc.contributor.author | Beitia Oyarzabal, Garikotiz | |
dc.contributor.author | Muñoz Culla, Maider | |
dc.contributor.author | Azkona Mendoza, Garikoitz | |
dc.contributor.author | Vegas Moreno, Oscar | |
dc.date.accessioned | 2024-06-10T17:28:03Z | |
dc.date.available | 2024-06-10T17:28:03Z | |
dc.date.issued | 2024-06-06 | |
dc.identifier.citation | NeuroSci 5(2) : 192-200 (2024) | es_ES |
dc.identifier.issn | 2673-4087 | |
dc.identifier.uri | http://hdl.handle.net/10810/68396 | |
dc.description.abstract | Evidence indicates that chronic social stress plays a significant role in the development of cancer and depression. Although their association is recognized, the precise physiological mechanism remains unknown. In our previous work, we observed that OF1 males subjected to chronic social de- fiance exhibited anhedonia, and those who developed tumors in the lung showed anxiety-associated behaviors. In this study, we observed that tumor-bearing OF1 mice presented higher levels of 3-HK, and this increase may be due to IDO. No differences in hippocampal catecholamine levels were ob- served. Our results suggest that a systemic tumor can induce molecular changes in the hippocampal kynurenine pathway that may impact behavior. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | chronic social stress | es_ES |
dc.subject | monoamines | es_ES |
dc.subject | kynurenine pathway | es_ES |
dc.subject | tumor development | es_ES |
dc.subject | hippocampus | es_ES |
dc.title | Systemic Tumors Can Cause Molecular Changes in the Hippocampus That May Have an Impact on Behavior after Chronic Social Stress | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2673-4087/5/2/14 | es_ES |
dc.identifier.doi | 10.3390/neurosci5020014 | |
dc.departamentoes | Psicología Clínica y de la Salud y Metodología de Investigación | es_ES |
dc.departamentoes | Procesos psicológicos básicos y su desarrollo | es_ES |
dc.departamentoeu | Psikologia Klinikoa eta Osasunaren Psikologia eta Ikerketa Metodologia | es_ES |
dc.departamentoeu | Oinarrizko psikologia prozesuak eta haien garapena | es_ES |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).