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dc.contributor.authorSilventoinen, Karri
dc.contributor.authorJelenkovic Moreno, Aline
dc.contributor.authorSund, Reijo
dc.contributor.authorYokoyama, Yoshie
dc.contributor.authorHur, Yoon-Mi
dc.contributor.authorCozen, Wendy
dc.contributor.authorHwang, Amie E.
dc.contributor.authorMack, Thomas M.
dc.contributor.authorHonda, Chika
dc.contributor.authorInui, Fujio
dc.contributor.authorIwatani, Yoshinori
dc.contributor.authorWatanabe, Mikio
dc.contributor.authorTomizawa, Rie
dc.contributor.authorPietiläinen, Kirsi H.
dc.contributor.authorRissanen, Aila
dc.contributor.authorSiribaddana, Sisira H.
dc.contributor.authorHotopf, Matthew
dc.contributor.authorSumathipala, Athula
dc.contributor.authorRijsdijk, Fruhling
dc.contributor.authorTan, Qihua
dc.contributor.authorZhang, Dongfeng
dc.contributor.authorPang, Zengchang
dc.contributor.authorPiirtola, Maarit
dc.contributor.authorAaltonen, Sari
dc.contributor.authorÖncel, Sevgi Y.
dc.contributor.authorAliev, Fazil
dc.contributor.authorRebato, Esther
dc.contributor.authorHjelmborg, Jacob B.
dc.contributor.authorChristensen, Kaare
dc.contributor.authorSkytthe, Axel
dc.contributor.authorKyvik, Kirsten O.
dc.contributor.authorSilberg, Judy L.
dc.contributor.authorEaves, Lindon J.
dc.contributor.authorCutler, Tessa L.
dc.contributor.authorOrdoñana, Juan R.
dc.contributor.authorSánchez- Romera, Juan F.
dc.contributor.authorColodro-Conde, Lucia
dc.contributor.authorSong, Yun-Mi
dc.contributor.authorYang, Sarah
dc.contributor.authorLee, Kayoung
dc.contributor.authorFranz, Carol E.
dc.contributor.authorKremen, William S.
dc.contributor.authorLyons, Michael J.
dc.contributor.authorBusjahn, Andreas
dc.contributor.authorNelson, Tracy L.
dc.contributor.authorWhitfield, Keith E.
dc.contributor.authorKandler, Christian
dc.contributor.authorJang, Kerry L.
dc.contributor.authorGatz, Margaret
dc.contributor.authorButler, David A.
dc.contributor.authorStazi, Maria A.
dc.contributor.authorFagnani, Corrado
dc.contributor.authorD’Ippolito, Cristina
dc.contributor.authorDuncan, Glen E.
dc.contributor.authorBuchwald, Dedra
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorJeong, Hoe-Uk
dc.contributor.authorSwan, Gary E.
dc.contributor.authorKrasnow, Ruth
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorDahl Aslan, Anna K.
dc.contributor.authorMcAdams, Tom A.
dc.contributor.authorEley, Thalia C.
dc.contributor.authorGregory, Alice M.
dc.contributor.authorTynelius, Patrik K. E.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorDahl Aslan, Anna K.
dc.contributor.authorMcAdams, Tom A.
dc.contributor.authorEley, Thalia C.
dc.contributor.authorGregory, Alice M.
dc.contributor.authorTynelius, Per
dc.contributor.authorBaker, Laura A.
dc.contributor.authorTuvblad, Catherine
dc.contributor.authorBayasgalan, Gombojav
dc.contributor.authorNarandalai, Danshiitsoodol
dc.contributor.authorSpector, Timothy D.
dc.contributor.authorMangino, Massimo
dc.contributor.authorLachance, Genevieve
dc.contributor.authorBurt, S. Alexandra
dc.contributor.authorKlump, Kelly L.
dc.contributor.authorHarris, Jennifer R.
dc.contributor.authorBrandt, Ingunn
dc.contributor.authorNilsen, Thomas S.
dc.contributor.authorKrueger, Robert F.
dc.contributor.authorMcGue, Matt
dc.contributor.authorPahlen, Shandell
dc.contributor.authorCorley, Robin P.
dc.contributor.authorHuibregtse, Brooke M.
dc.contributor.authorBartels, Meike
dc.contributor.authorvan Beijsterveldt, Catharina E. M.
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorGoldberg, Jack H.
dc.contributor.authorRasmussen, Finn
dc.contributor.authorTarnoki, Adam D.
dc.contributor.authorTarnoki, David L.
dc.contributor.authorDerom, Catherine A.
dc.contributor.authorVlietinck, Robert F.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorHopper, John L.
dc.contributor.authorSung, Joohon
dc.contributor.authorMaes, Hermine H.
dc.contributor.authorTurkheimer, Eric
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorSørensen, Thorkild I. A.
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2024-07-02T16:08:35Z
dc.date.available2024-07-02T16:08:35Z
dc.date.issued2017-07-05
dc.identifier.citationThe American Journal of Clinical Nutrition 106(2) : 457-466 (2017)es_ES
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttp://hdl.handle.net/10810/68741
dc.description.abstractBackground Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood. Objective We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20–29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70–79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20–29 to 60–69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBMIes_ES
dc.subjectadultses_ES
dc.subjectgeneticses_ES
dc.subjecttwinses_ES
dc.subjectinternational comparisonses_ES
dc.titleDifferences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohortses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2017 American Society for Nutrition. Published by Elsevier Inc.under CC BY-NC-ND licensees_ES
dc.relation.publisherversionhttps://doi.org/10.3945/ajcn.117.153643es_ES
dc.identifier.doi10.3945/ajcn.117.153643
dc.departamentoesGenética, antropología física y fisiología animales_ES
dc.departamentoeuGenetika,antropologia fisikoa eta animalien fisiologiaes_ES


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© 2017 American Society for Nutrition. Published by Elsevier Inc.under CC BY-NC-ND license
Except where otherwise noted, this item's license is described as © 2017 American Society for Nutrition. Published by Elsevier Inc.under CC BY-NC-ND license