dc.contributor.author | Aparicio Fernández, Leire | |
dc.contributor.author | Antoran Díaz, Aitziber | |
dc.contributor.author | Areitio Beramendi, Maialen | |
dc.contributor.author | Rodríguez Ereñaga, Oier | |
dc.contributor.author | Martín Souto, Leire | |
dc.contributor.author | Buldain Garriz, Idoia | |
dc.contributor.author | Márquez Clavijo, Joana | |
dc.contributor.author | Benedicto García, Aitor | |
dc.contributor.author | Arteta Ruiz, Beatriz | |
dc.contributor.author | Pellón Rodríguez, Aize | |
dc.contributor.author | Moyes, David L. | |
dc.contributor.author | Rementeria Ruiz, Aitor Domingo | |
dc.contributor.author | Ramírez García, Andoni | |
dc.date.accessioned | 2024-07-04T16:32:55Z | |
dc.date.available | 2024-07-04T16:32:55Z | |
dc.date.issued | 2024-05 | |
dc.identifier.citation | Microbes and Infection 26(4) : (2024) // Article ID 105305 | es_ES |
dc.identifier.issn | 1769-714X | |
dc.identifier.uri | http://hdl.handle.net/10810/68769 | |
dc.description.abstract | The liver, and more specifically, the liver sinusoidal endothelial cells, constitute the beginning of one of the most important responses for the elimination of hematogenously disseminated Candida albicans. Therefore, we aimed to study the mechanisms involved in the interaction between these cells and C. albicans. Transcriptomics-based analysis showed an increase in the expression of genes related to the immune response (including receptors, cytokines, and adhesion molecules), as well as to aerobic glycolysis. Further in vitro analyses showed that IL-6 production in response to C. albicans is controlled by MyD88- and SYK-pathways, suggesting an involvement of Toll-like and C-type lectin receptors and the subsequent activation of the MAP-kinases and c-Fos/AP-1 transcription factor. In addition, liver sinusoidal endothelial cells undergo metabolic reprogramming towards aerobic glycolysis induced by C. albicans, as confirmed by the increased Extracellular Acidification Rate and the overexpression of enolase (Eno2), hexonikase (Hk2) and glucose transporter 1 (Slc2a1). In conclusion, these results indicate that the hepatic endothelium responds to C. albicans by increasing aerobic glycolysis and promoting an inflammatory environment. | es_ES |
dc.description.sponsorship | This research was funded by the Basque Government, grant numbers IT1362-19 and IT1657-22, and the Spanish Ministry of Science via FECYT, grant number PRECIPITA_PR251. L.M−S and M.A have received a predoctoral grant from the Basque Government and L.A-F from the University of the Basque Country (UPV/EHU). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | liver endothelium | es_ES |
dc.subject | Candida | es_ES |
dc.subject | inflammation | es_ES |
dc.subject | metabolism | es_ES |
dc.subject | immune response | es_ES |
dc.subject | aerobic glycolysis | es_ES |
dc.title | Candida albicans increases the aerobic glycolysis and activates MAPK–dependent inflammatory response of liver sinusoidal endothelial cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open
access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S128645792400025X | es_ES |
dc.identifier.doi | 10.1016/j.micinf.2024.105305 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |