dc.contributor.author | González Pujana, Ainhoa | |
dc.contributor.author | Igartua Olaechea, Manuela | |
dc.contributor.author | Hernández Martín, Rosa María | |
dc.contributor.author | Santos Vizcaíno, Edorta | |
dc.date.accessioned | 2024-08-06T11:05:39Z | |
dc.date.available | 2024-08-06T11:05:39Z | |
dc.date.issued | 2024-10 | |
dc.identifier.citation | European Journal of Pharmaceutical Sciences 201 : (2024) // Article ID 106858 | es_ES |
dc.identifier.issn | 1879-0720 | |
dc.identifier.uri | http://hdl.handle.net/10810/69173 | |
dc.description.abstract | Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as a promising candidate for their sustained delivery. Despite its unique properties allow to load and release proteins mitigating burst release and extending their effects, precise control over Laponite-protein interactions remains challenging since it depends on a complex interplay of factors whose implication is not fully understood yet. The aim of this review article is to shed light on this issue, providing a comprehensive discussion of the factors influencing protein loading and release, including the physicochemical properties of the nanoclay and proteins, pH, dispersion buffer, clay/protein concentration and Laponite degradation. Furthermore, we thoroughly revise the array of bioactive proteins that have been delivered from formulations containing the nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, a promising avenue currently under extensive investigation. | es_ES |
dc.description.sponsorship | This work was supported by MCIU-Proyectos de Investigación Orientada (PID2021-122577OB-I00) and Eusko Jaurlaritza (Grupos Consolidados IT1448-22). Authors thank ICTS “NANBIOSIS” (Drug Formulation Unit, U10). A. Gonzalez-Pujana thanks the University of the Basque Country (UPV/EHU) for the postdoctoral grant (ESPDOC20/119). Fig. 1 was created with BioRender.com. Open Access funding provided by University of Basque Country (UPV/EHU). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2021-122577OB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | laponite | es_ES |
dc.subject | nanoclay | es_ES |
dc.subject | drug delivery | es_ES |
dc.subject | protein | es_ES |
dc.subject | hydrogel | es_ES |
dc.title | Laponite nanoclays for the sustained delivery of therapeutic proteins | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0928098724001702 | es_ES |
dc.identifier.doi | 10.1016/j.ejps.2024.106858 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |