dc.contributor.author | Regato Herbella, María | |
dc.contributor.author | Mantione, Daniele | |
dc.contributor.author | Blanchman, Agustín | |
dc.contributor.author | Gallastegui, Antonela | |
dc.contributor.author | Calabrese, Graciela C. | |
dc.contributor.author | Moya, Sergio Enrique | |
dc.contributor.author | Mecerreyes Molero, David | |
dc.contributor.author | Criado González, Miryam | |
dc.date.accessioned | 2024-08-30T08:43:41Z | |
dc.date.available | 2024-08-30T08:43:41Z | |
dc.date.issued | 2024-08 | |
dc.identifier.citation | ACS Macro Letters 13 : 1119-1126 (2024) | es_ES |
dc.identifier.issn | 2161-1653 | |
dc.identifier.uri | http://hdl.handle.net/10810/69356 | |
dc.description.abstract | Multiresponsive hydrogels are valuable as biomaterials due to their ability to respond to multiple biologically relevant stimuli, i.e., temperature, pH, or reactive oxygen species (ROS), which can be present simultaneously in the body. In this work, we synthesize triple-responsive hydrogels through UV light photopolymerization of selected monomer compositions that encompass thermoresponsive N-isopropylacrylamide (NIPAM), pH-responsive methacrylic acid (MAA), and a tailor-made ROS-responsive diacrylate thioether monomer (EG3SA). As a result, smart P[NIPAMx-co-MAAy-co-(EG3SA)z] hydrogels capable of being manufactured by digital light processing (DLP) 4D printing are obtained. The thermo-, pH-, and ROS-response of the hydrogels are studied by swelling tests and rheological measurements at different temperatures (25 and 37 °C), pHs (3, 5, 7.4, and 11), and in the absence or presence of ROS (H2O2). The hydrogels are employed as matrixes for the encapsulation of ketoprofen (KET), an anti-inflammatory drug that shows a tunable release, depending on the hydrogel composition and stimuli applied. The cytotoxicity properties of the hydrogels are tested in vitro with mouse embryonic fibroblasts (NIH 3T3) and RAW 264.7 murine macrophage (RAW) cells. Finally, the anti-inflammatory properties are assessed, and the results exhibit a ≈70% nitric oxide reduction up to base values of pro-inflammatory RAW cells, which highlights the anti-inflammatory capacity of P[NIPAM80-co-MAA15-co-(EG3SA)5] hydrogels, per se, without being necessary to encapsulate an anti-inflammatory drug within their network. It opens the route for the fabrication of customizable 4D printable scaffolds for the effective treatment of inflammatory pathologies. | es_ES |
dc.description.sponsorship | The authors acknowledge Grant PID2020-119026GB-I00 funded by MCIU/AEI/10.13039/501100011033. M.C.-G. thanks the Emakiker program of POLYMAT (UPV/EHU). S.E.M. thanks the PID2020-114356RB-I00 Project from the Ministry of Science and Innovation of the Government of Spain. D.M. thanks “Ayuda RYC2021-031668-I financiada por MCIN/AEI/10.13039/501100011033 y por la Unión Europea NextGenerationEU/PRTR”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACS | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-119026GB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-114356RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/RYC2021-031668-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | Multiresponsive 4D Printable Hydrogels with Anti-Inflammatory Properties | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Authors. Published by American Chemical Society. This publication is licensed under
CC-BY 4.0. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://pubs.acs.org/doi/full/10.1021/acsmacrolett.4c00404 | es_ES |
dc.identifier.doi | 10.1021/acsmacrolett.4c00404 | |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |