dc.contributor.author | Simhadri, V. R. | |
dc.contributor.author | Dimitrova, M. | |
dc.contributor.author | Mariano, J. L. | |
dc.contributor.author | Zenarruzabeitia Belaustegui, Olatz | |
dc.contributor.author | Zhong, W. | |
dc.contributor.author | Ozawa, T. | |
dc.contributor.author | Muraguchi, A. | |
dc.contributor.author | Kishi, H. | |
dc.contributor.author | Eichelberger, M. C. | |
dc.contributor.author | Borrego Rabasco, Francisco | |
dc.date.accessioned | 2024-09-05T14:37:13Z | |
dc.date.available | 2024-09-05T14:37:13Z | |
dc.date.issued | 2015-04-27 | |
dc.identifier.citation | PLoS One10(4) : (2015) // Article ID e0124677. | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/69424 | |
dc.description.abstract | The highly conserved matrix protein 2 (M2) is a good candidate for the development of a broadly protective influenza vaccine that induces long-lasting immunity. In animal models, natural killer (NK) cells have been proposed to play an important role in the protection provided by M2-based vaccines through a mechanism of antibody-dependent cell mediated cytotoxicity (ADCC). We investigated the ability of the human anti-M2 Ab1-10 monoclonal antibody (mAb) to activate human NK cells. They mediated ADCC against M2-expressing cells in the presence of Ab1-10 mAb. Furthermore, NK cell pro-inflammatory cytokine and chemokine secretion is also enhanced when Ab1-10 mAb is present. We also generated cytokine preactivated NK cells and showed that they still displayed increased effector functions in the presence of Ab1-10 mAb. Thus, our study has demonstrated that human resting and cytokine preactivated NK cells may have a very important role in the protection provided by anti-M2 Abs. | es_ES |
dc.description.sponsorship | Medical Counter Measures initiatives (MCMi) grant (F6). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | NK cells | es_ES |
dc.subject | ADCC | es_ES |
dc.title | A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine preactivated natural killer (NK) cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | (cc) The AuthorsThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0124677 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0124677 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |