Temporal and spatial resolution of magnetosome degradation at the subcellular level in a 3D lung carcinoma model
dc.contributor.author | Gascón Fernández Gubieda, Alicia | |
dc.contributor.author | Gandarias Albaina, Lucia | |
dc.contributor.author | Pósfai, Mihály | |
dc.contributor.author | Pattammattel, Ajith | |
dc.contributor.author | Fernández Gubieda Ruiz, María Luisa | |
dc.contributor.author | Abad Díaz de Cerio, Ana | |
dc.contributor.author | García Prieto, Ana | |
dc.date.accessioned | 2024-09-11T17:48:52Z | |
dc.date.available | 2024-09-11T17:48:52Z | |
dc.date.issued | 2024-09 | |
dc.identifier.citation | Journal of Nanobiotechnology 22 : (2024) // Article ID 529 | es_ES |
dc.identifier.issn | 1477-3155 | |
dc.identifier.uri | http://hdl.handle.net/10810/69471 | |
dc.description.abstract | Magnetic nanoparticles offer many exciting possibilities in biomedicine, from cell imaging to cancer treatment. One of the currently researched nanoparticles are magnetosomes, magnetite nanoparticles of high chemical purity synthesized by magnetotactic bacteria. Despite their therapeutic potential, very little is known about their degradation in human cells, and even less so of their degradation within tumours. In an effort to explore the potential of magnetosomes for cancer treatment, we have explored their degradation process in a 3D human lung carcinoma model at the subcellular level and with nanometre scale resolution. We have used state of the art hard X-ray probes (nano-XANES and nano-XRF), which allow for identification of distinct iron phases in each region of the cell. Our results reveal the progression of magnetite oxidation to maghemite within magnetosomes, and the biosynthesis of magnetite and ferrihydrite by ferritin. | es_ES |
dc.description.sponsorship | This work was supported by grants PID2020-115704RB-C31 funded by the Spanish Ministerio de Ciencia, Innovación y Universidades (MCIN/AEI/10.13039/501100011033) , and by IT1479-22 funded by the Basque Government. Electron microscopy performed at Nanolab, University of Pannonia was supported by the Hungarian National Research, Development and Innovation Office (NKFIH) under grant RRF-2.3.1-21-2022-00014. This research used resources HXN (3-ID) of the National Synchrotron Light Source II, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under Contract No. DE-SC0012704. European Synchrotron Radiation Facility (ESRF) provided beamtime at BM23 beamline. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-115704RB-C31 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Temporal and spatial resolution of magnetosome degradation at the subcellular level in a 3D lung carcinoma model | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-024-02788-8 | es_ES |
dc.identifier.doi | 10.1186/s12951-024-02788-8 | |
dc.departamentoes | Electricidad y electrónica | es_ES |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Elektrizitatea eta elektronika | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you
give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the
licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or
other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation
or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://
creativecommons.org/licenses/by-nc-nd/4.0/