Neurolipid systems: A new target for the treatment of dementia
dc.contributor.author | Pereira Castelo, Gorka | |
dc.contributor.author | Bengoetxea de Tena, Iker | |
dc.contributor.author | Martínez Gardeazabal, Jonatan | |
dc.contributor.author | Moreno Rodríguez, Marta | |
dc.contributor.author | González de San Román, Estíbaliz | |
dc.contributor.author | Manuel Vicente, Iván | |
dc.contributor.author | Rodríguez Puertas, Rafael | |
dc.date.accessioned | 2024-09-16T15:21:48Z | |
dc.date.available | 2024-09-16T15:21:48Z | |
dc.date.issued | 2024-09-22 | |
dc.identifier.citation | Basic & Clinical Pharmacology & Toxicology 135(3) : 225-236 (2024) | es_ES |
dc.identifier.issn | 1742-7843 | |
dc.identifier.uri | http://hdl.handle.net/10810/69487 | |
dc.description.abstract | Neurolipids comprise a diverse class of bioactive lipids that include molecules capable of activating G protein-coupled receptors, thereby inducing systemic effects that contribute to the maintenance of homeostasis. Dementia, a non-specific brain disorder characterized by a common set of signs and symptoms, usually arises subsequent to brain injuries or diseases and is often associated with the aging process. Individuals affected by dementia suffer from the disruption of several neurotransmitter and neuromodulatory systems, among which neurolipids play an important role, including the endocannabinoid, lysophosphatidic acid and sphingosine 1-phosphate systems. In this review, we present an overview of the most recent and pertinent findings regarding the involvement of these neurolipidic systems in dementia, including data from a wide range of both in vitro and in vivo experiments as well as clinical trials. | es_ES |
dc.description.sponsorship | This work was supported by grants from Basque Government IT1454-22 to the ‘Neurochemistry and Neurodegeneration’ consolidated research group and by Instituto de Salud Carlos III through the project ‘PI20/00153’ (co-funded by European Regional Development Fund ‘A way to make Europe’) and by BIOEF project BIO22/ALZ/010 funded by Eitb Maratoia. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | dementia | es_ES |
dc.subject | endocannabinoid | es_ES |
dc.subject | lysophosphatidic acid | es_ES |
dc.subject | neurolipid | es_ES |
dc.subject | sphingosine 1phosphate | es_ES |
dc.title | Neurolipid systems: A new target for the treatment of dementia | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Author(s). Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.14059 | es_ES |
dc.identifier.doi | 10.1111/bcpt.14059 | |
dc.departamentoes | Farmacología | es_ES |
dc.departamentoeu | Farmakologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2024 The Author(s). Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.