Show simple item record

dc.contributor.authorAlart Lorenzo, Jon Ander
dc.contributor.authorÁlvarez Díaz, Antonia Ángeles
dc.contributor.authorCatalán Alcántara, Ana ORCID
dc.contributor.authorHerrero de la Parte, Borja
dc.contributor.authorAlonso Alconada, Daniel ORCID
dc.date.accessioned2024-09-27T14:51:00Z
dc.date.available2024-09-27T14:51:00Z
dc.date.issued2024-09-16
dc.identifier.citationAntioxidants 13(9) : (2024) // Article ID 1122es_ES
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10810/69583
dc.description.abstractNeonatal hypoxia–ischemia is a major cause of infant death and disability. The only clinically accepted treatment is therapeutic hypothermia; however, cooling is less effective in the most severely encephalopathic infants. Here, we wanted to test the neuroprotective effect of the antioxidant dimethyl fumarate after severe hypoxia–ischemia in neonatal rats. We used a modified Rice–Vannucci model to generate severe hypoxic–ischemic brain damage in day 7 postnatal rats, which were randomized into four experimental groups: Sham, Sham + DMF, non-treated HI, and HI + DMF. We analyzed brain tissue loss, global and regional (cortex and hippocampus) neuropathological scores, white matter injury, and microglial and astroglial reactivity. Compared to non-treated HI animals, HI + DMF pups showed a reduced brain area loss (p = 0.0031), an improved neuropathological score (p = 0.0016), reduced white matter injuries by preserving myelin tracts (p < 0.001), and diminished astroglial (p < 0.001) and microglial (p < 0.01) activation. After severe hypoxia–ischemia in neonatal rats, DMF induced a strong neuroprotective response, reducing cerebral infarction, gray and white matter damage, and astroglial and microglial activation. Although further molecular studies are needed and its translation to human babies would need to evaluate the molecule in piglets or lambs, DMF may be a potential treatment against neonatal encephalopathy.es_ES
dc.description.sponsorshipThis research was funded by the University of the Basque Country (UPV/EHU), grant number GIU21/054 and J.A.A. was funded by Programa Investigo funded by EU-Next Generation, grant number PIFINVE22/14.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/es/
dc.subjectneonatal brain injuryes_ES
dc.subjecthypoxia–ischemiaes_ES
dc.subjectdimethyl fumaratees_ES
dc.subjectneuroprotectiones_ES
dc.subjectwhite matter injuryes_ES
dc.subjectmicrogliaes_ES
dc.subjectastrogliaes_ES
dc.titleDimethyl Fumarate Strongly Ameliorates Gray and White Matter Brain Injury and Modulates Glial Activation after Severe Hypoxia–Ischemia in Neonatal Ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2024-09-27T13:19:59Z
dc.rights.holder© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/13/9/1122es_ES
dc.identifier.doi10.3390/antiox13091122
dc.departamentoesBiología celular e histología
dc.departamentoesNeurociencias
dc.departamentoesCirugía, radiología y medicina física
dc.departamentoeuZelulen biologia eta histologia
dc.departamentoeuNeurozientziak
dc.departamentoeuKirurgia,erradiologia eta medikuntza fisikoa


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).