dc.contributor.author | Udabe, Jakes | |
dc.contributor.author | Martín Saldaña, Sergio | |
dc.contributor.author | Tao, Yushi | |
dc.contributor.author | Picchio, Matías L. | |
dc.contributor.author | Beloqui Elizazu, Ana | |
dc.contributor.author | Paredes, Alejandro Javier | |
dc.contributor.author | Calderón, Marcelo | |
dc.date.accessioned | 2024-10-08T16:51:41Z | |
dc.date.available | 2024-10-08T16:51:41Z | |
dc.date.issued | 2024-09 | |
dc.identifier.citation | ACS Applied Materials & Interfaces 16(36) : 47124-47136 (2024) | es_ES |
dc.identifier.issn | 1944-8244 | |
dc.identifier.issn | 1944-8252 | |
dc.identifier.uri | http://hdl.handle.net/10810/69790 | |
dc.description.abstract | Nanocrystals (NCs) have entirely changed the panorama of hydrophobic drug delivery, showing improved biopharmaceutical performance through multiple administration routes. NCs are potential highly loaded nanovectors due to their pure drug composition, standing out from conventional polymers and lipid nanoparticles that have limited drug-loading capacity. However, research in this area is limited. This study introduces the concept of surface modification of drug NCs through single-layer poly(ethylene glycol) (PEG) polymerization as an innovative strategy to boost targeting efficiency. The postpolymerization analysis revealed size and composition alterations, indicating successful surface engineering of NCs of the model drug curcumin of approximately 200 nm. Interestingly, mucosal tissue penetration analysis showed enhanced entry for fully coated and low cross-linked (LCS) PEG NCs, with an increase of 15 μg/cm2 compared to the control NCs. In addition, we found that polymer chemistry variations on the NCs’ surface notably impacted mucin binding, with those armored with LCS PEG showing the most significant reduction in interaction with this glycoprotein. We validated this strategy in an in vitro nose-to-brain model, with all of the NCs exhibiting a promising ability to cross a tight monolayer. Furthermore, the metabolic and pro-inflammatory activity revealed clear indications that, despite surface modifications, the efficacy of curcumin remains unaffected. These findings highlight the potential of surface PEGylated NCs in targeted drug delivery. Altogether, this work sets the baseline for further exploration and optimization of surface polymerized NCs for enhanced drug delivery applications, promising more efficient treatments for specific disorders and conditions requiring active targeting. | es_ES |
dc.description.sponsorship | M.C. acknowledges the financial support of the Basque Government (projects 2023333010, 2023333023, PIBA2023-1-0043), the University of the Basque Country (projects COLLAB22/05 and GIU21/033), the IKERBASQUE-Basque Foundation for Science, and the Ministry of Science and Innovation of the Government of Spain (grant PID2022-142739OB-I00 funded by MICIU/AEI/10.13039/501100011033 and by FEDER, UE; “María de Maeztu” Programme for Center of Excellence in R&D, grant CEX2023-001303-M funded by MICIU/AEI/10.13039/501100011033; FPI Fellowship PRE2019-088584). S.M.-S. has received support from the IKUR Strategy of the Basque Government. MLP has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 101028881. A.B. gratefully acknowledges the financial support from the Spanish Research Agency (AEI) (PID2022-142128NB-I00 funded by MCIN/AEI/10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”; RYC2018-025923-I from RyC program-MCIN/AEI/10.13039/501100011033 and FSE “invierte en tu futuro”) and Basque Government (Elkartek, KK-2022/00008). A.J.P. acknowledges the financial support by the Royal Society (grant RGS\R1\231342) and the Engineering and Physical Sciences Research Council (grant EP/Y001486/1). The authors thank the UPV/EHU for the technical and human support provided by the SGIker services and Dr. Soledad Orellano for her assistance with the fluorescence microscopy studies. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACS | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/101028881 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2022-142739OB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2022-142128NB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RYC2018-025923-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | nanocrystals | es_ES |
dc.subject | polyethyleneglycol (PEG) | es_ES |
dc.subject | mucin | es_ES |
dc.subject | surface chemistry | es_ES |
dc.subject | nose-to-brain route | es_ES |
dc.subject | targeted delivery | es_ES |
dc.title | Unveiling the Potential of Surface Polymerized Drug Nanocrystals in Targeted Delivery | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Authors. Published by American Chemical Society. This publication is licensed under
CC-BY 4.0 . | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acsami.4c07669 | es_ES |
dc.identifier.doi | 10.1021/acsami.4c07669 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |