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dc.contributor.authorMihalik, Stephanie J.
dc.contributor.authorMichaliszyn, Sara F.
dc.contributor.authorDe las Heras Montero, Javier Adolfo
dc.contributor.authorBacha, Fida
dc.contributor.authorChace, Donald H.
dc.contributor.authorLee, SoJung
dc.contributor.authorChace, Donald H.
dc.contributor.authorDeJesus, Victor R.
dc.contributor.authorVockley, Jerry
dc.contributor.authorArslanian, Silva A.
dc.date.accessioned2024-10-15T12:29:30Z
dc.date.available2024-10-15T12:29:30Z
dc.date.issued2012
dc.identifier.citationDiabetes Care 35(3) : 605-611 (2012)es_ES
dc.identifier.issn0149-5992
dc.identifier.issn1935-5548
dc.identifier.urihttp://hdl.handle.net/10810/69941
dc.description.abstractOBJECTIVE We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents. RESEARCH DESIGN AND METHODS Fasting plasma was analyzed by tandem mass spectrometry, body composition by dual energy X-ray absorptiometry and computed tomography, and total-body lipolysis and substrate oxidation by [2H5]glycerol and indirect calorimetry, respectively. In vivo insulin sensitivity (IS) was assessed with a 3-h hyperinsulinemic-euglycemic clamp. RESULTS Long-chain AcylCNs (C18:2-CN to C14:0-CN) were similar among the three groups. Medium- to short-chain AcylCNs (except C8 and C10) were significantly lower in type 2 diabetes compared with NW, and when compared with OB, C2-, C6-, and C10-CN were lower. Amino acid concentrations were lower in type 2 diabetes compared with NW. Fasting lipolysis and FOX were higher in OB and type 2 diabetes compared with NW, and the negative association of FOX to C10:1 disappeared after controlling for adiposity, Tanner stage, and sex. IS was lower in OB and type 2 diabetes with positive associations between IS and arginine, histidine, and serine after adjusting for adiposity, Tanner stage, and sex. CONCLUSIONS These metabolomics results, together with the increased rates of in vivo FOX, are not supportive of defective fatty acid or amino acid metabolism in obesity and type 2 diabetes in youth. Such observations are consistent with early adaptive metabolic plasticity in youth, which over time—with continued obesity and aging—may become dysfunctional, as observed in adults.es_ES
dc.description.sponsorshiphis study was supported by grants R01 HD-27503 (S.A.A.) and K24 HD-01357 (S.A.A.), the Richard L. Day Endowed Chair (S.A.A.), the Department of Defense (S.A.A., S.J.L., and F.B.), American Diabetes Association Grant 7-08-JF-27 (S.J.L.), the Thrasher Research Fund (F.B.), and National Institutes of Health grants ROI DK-78775 (J.V.) and UL1 RR024153 CTSA (previously M01_RR-00084).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Diabetes Associationes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleMetabolomic Profiling of Fatty Acid and Amino AcidMetabolism in Youth With Obesity and Type 2 Diabeteses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.es_ES
dc.relation.publisherversionhttps://diabetesjournals.org/care/article/35/3/605/28755/Metabolomic-Profiling-of-Fatty-Acid-and-Amino-Acides_ES
dc.identifier.doi10.2337/DC11-1577
dc.departamentoesPediatríaes_ES
dc.departamentoeuPediatriaes_ES


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This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
Except where otherwise noted, this item's license is described as This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.