Advanced functional materials and cell-based therapies for the treatment of ischemic stroke and postischemic stroke effects
dc.contributor.author | Tapeinos, Christos | |
dc.contributor.author | Larrañaga Espartero, Aitor | |
dc.contributor.author | Tomatis, Francesca | |
dc.contributor.author | Bizeau, Joëlle | |
dc.contributor.author | Marino, Attilio | |
dc.contributor.author | Battaglini, Matteo | |
dc.contributor.author | Pandit, Abhay | |
dc.contributor.author | Ciofani, Gianni | |
dc.date.accessioned | 2024-10-15T14:49:06Z | |
dc.date.available | 2024-10-15T14:49:06Z | |
dc.date.issued | 2020-01 | |
dc.identifier.citation | Advanced Functional Materials 30(1) : (2020) // Article ID 1906283 | es_ES |
dc.identifier.issn | 1616-3028 | |
dc.identifier.issn | 1616-301X | |
dc.identifier.uri | http://hdl.handle.net/10810/69954 | |
dc.description.abstract | Ischemic stroke is considered one of the most threatening neurological disorders with high percentages of mortality and morbidity worldwide. Although in recent years, several nanotechnological advances have improved the survival rates, severe untreated poststroke side-effects continue to significantly influence the way of life of many. Tissue plasminogen activator and mechanical thrombectomy are considered the gold standards for the treatment of acute cerebral ischemia. These, however, fail to improve postischemic disorders. Herein, after a brief description of the pathophysiology of ischemic stroke and the following biochemical cascade, the most recent biomaterial and cell-based strategies are reviewed for its treatment. Other therapeutics that have been proposed not only for the treatment of cerebral ischemia but also for the regeneration of the infarcted brain that is responsible for a variety of disorders, including cognitive, motor, and speech problems are also presented. Finally, a few reported studies on diagnostic and theranostic nanostructures are also provided. | es_ES |
dc.description.sponsorship | This research was performed within the framework of the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 793644 (BIONICS). This project was funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2015) under the Marie Skłodowska-Curie Innovative Training Network and Grant Agreement No. 676408. Research grant from Science Foundation Ireland (SFI) cofunded under the European Regional Development Fund under Grant No. 13/RC/2073 is also acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/793644 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/676408 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.title | Advanced functional materials and cell-based therapies for the treatment of ischemic stroke and postischemic stroke effects | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201906283 | es_ES |
dc.identifier.doi | 10.1002/adfm.201906283 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | es_ES |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia | es_ES |
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Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.