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Brønsted Acid Catalyzed (4 + 2) Cyclocondensation of 3-Substituted Indoles with Donor–Acceptor Cyclopropanes

dc.contributor.authorOrtega, Alesandere
dc.contributor.authorUria Pujana, Uxue ORCID
dc.contributor.authorTejero, Tomás
dc.contributor.authorPrieto Aretxabaleta, Liher ORCID
dc.contributor.authorReyes Martín, Efraim
dc.contributor.authorMerino, Pedro
dc.contributor.authorVicario Hernando, José Luis ORCID
dc.date.accessioned2024-10-15T16:02:22Z
dc.date.available2024-10-15T16:02:22Z
dc.date.issued2021-03
dc.identifier.citationOrganic Letters 23(6) : 2326-2331 (2021)es_ES
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.urihttp://hdl.handle.net/10810/69960
dc.description.abstractAcylcyclopropanes are employed as useful donor−acceptor cyclopropanes that undergo formal (4 + 2) cyclo-condensation with N-unprotected 3-substituted indoles in thepresence of a Brønsted acid catalyst. The reaction involves thesimultaneous alkylation of both the N and C-2 positions of theindole and provides access to the 8,9-dihydropyrido[1,2-a]indolescaffold that is the central core of several biologically relevantindole alkaloids in excellent yields and good selectivitieses_ES
dc.description.sponsorshipSpanish MINECO(PID2019-104090RB-100 and FEDER-CTQ2016-76155-R), Basque Government (IT908-16), UPV/EHU (fellowship to A.O.), and Government of Aragón (Grupos Consolidados,E34_20R).es_ES
dc.language.isoenges_ES
dc.publisherACS Publicationses_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-104090RB-100es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdonor−acceptor cyclopropaneses_ES
dc.subjectacylcyclopropaneses_ES
dc.subject(4 + 2) cyclocondensationes_ES
dc.subjectbrønsted acid catalyzedes_ES
dc.titleBrønsted Acid Catalyzed (4 + 2) Cyclocondensation of 3-Substituted Indoles with Donor–Acceptor Cyclopropaneses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2021 American Chemical Society . This publication is licensed under CC-BY 4.0es_ES
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.orglett.1c00470es_ES
dc.identifier.doi10.1021/acs.orglett.1c00470
dc.departamentoesQuímica Orgánica e Inorgánicaes_ES
dc.departamentoeuKimika Organikoa eta Ez-Organikoaes_ES


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© 2021 American Chemical Society . This publication is licensed under CC-BY 4.0
Except where otherwise noted, this item's license is described as © 2021 American Chemical Society . This publication is licensed under CC-BY 4.0