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dc.contributor.authorSalvador Martínez, Aiala
dc.contributor.authorIgartua Olaechea, Manuela
dc.contributor.authorHernández Martín, Rosa María
dc.contributor.authorPedraz Muñoz, José Luis
dc.date.accessioned2012-04-17T16:46:47Z
dc.date.available2012-04-17T16:46:47Z
dc.date.issued2011
dc.identifier.citationJournal of Drug Delivery 2011 : (2011) // Article ID 181646es
dc.identifier.issn2090-3014 (Print)
dc.identifier.issn2090-3022 (Online)
dc.identifier.urihttp://hdl.handle.net/10810/7351
dc.description18 p.es
dc.description.abstractThe development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a virulent form, allow a better conservation, and are produced more easily and safely. However, they generate a weaker immune response than other vaccines, and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed. Among vaccine delivery systems, micro- and nanoparticulated ones are attractive, because their particulate nature can increase cross-presentation of the peptide. In addition, they can be passively or actively targeted to antigen presenting cells. Furthermore, particulate adjuvants are able to directly activate innate immune system in vivo. Here, we summarize micro- and nanoparticulated vaccine delivery systems used in the field of synthetic peptide-based vaccines as well as strategies to increase their immunogenicity.es
dc.description.sponsorshipThis project was partially supported by the “Ministerio de Ciencia e Innovación” (SAF2007-66115) and FEDER funds. A. Salvador thanks the “Universidad del País Vasco” for the Fellowship Grant.es
dc.language.isoenges
dc.publisherHindawi Publishing Corporationes
dc.relationinfo:eu-repo/grantAgreement/MICINN/SAF2007-66115
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.titleAn Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccineses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderCopyright © 2011 Aiala Salvador et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es
dc.relation.publisherversionhttp://www.hindawi.com/journals/jdd/2011/181646/es
dc.identifier.doi10.1155/2011/181646
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES
dc.subject.categoriaPHARMACOLOGY, TOXICOLOGY AND PHARMACEUTICS


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