dc.contributor.author | Ibarretxe Bilbao, Gaskon | |
dc.contributor.author | Álvarez Díaz, Antonia Ángeles | |
dc.contributor.author | Cañavate Escribano, María Luz | |
dc.contributor.author | Hilario Rodríguez, Enrique | |
dc.contributor.author | Aurrekoetxea Campo, Maitane | |
dc.contributor.author | Unda Rodríguez, Fernando José | |
dc.date.accessioned | 2012-06-02T10:39:21Z | |
dc.date.available | 2012-06-02T10:39:21Z | |
dc.date.issued | 2012-03-29 | |
dc.identifier.citation | Stem Cells International 2012 : (2012) // Article ID 365932 | es |
dc.identifier.issn | 1687-9678 | |
dc.identifier.uri | http://hdl.handle.net/10810/7898 | |
dc.description | 8 p. | es |
dc.description.abstract | The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on IPS cells advises that research on their regenerative properties is carried out in appropriate tissue and organ systems that permit a safe assessment of the long-term behavior of these reprogrammed cells. In the present paper, we discuss the mechanisms of cell reprogramming, current technical limitations of IPS cells for their use in human tissue engineering, and possibilities to overcome them in the particular case of dental regeneration. | es |
dc.description.sponsorship | This work was supported by grants from the University of the Basque Country (UPV/EHU: GIU09/70, UFI11/44), Fondo de Investigación Sanitaria (FIS) of Spanish Ministry
of Health (PS09/02326), and the Basque Government (IT-287-07, BFI07.288 and SPE11UNO51). The authors thank
Professor David Hallett for the review of this paper. M. Aurrekoetxea holds a fellowship from the University of the
Basque Country (UPV/EHU). | es |
dc.language.iso | eng | es |
dc.publisher | SAGE-Hindawi Access to Research | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | IPS cells | es |
dc.subject | cell reprogramming | es |
dc.subject | generation | es |
dc.subject | human tissue engineering | es |
dc.subject | dental regeneration | es |
dc.title | Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | Copyright © 2012 Gaskon Ibarretxe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es |
dc.relation.publisherversion | http://www.hindawi.com/journals/sci/2012/365932/ | es |
dc.identifier.doi | 10.1155/2012/365932 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |
dc.subject.categoria | CELL BIOLOGY | |
dc.subject.categoria | MOLECULAR BIOLOGY | |