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Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
(MDPI, 2023-10-25)
Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative ...
Optimizing pharmacotherapy in the elderly using modelling and simulation methods. Application to Bilastine
(2021-11-29)
This research project was designed to acquire a deeper knowledge on how physiological changes during aging mayaffect the pharmacokinetics (PK) and pharmacodynamics (PD). Elderly adults are a vulnerable population due to ...
Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson’s Disease
(MDPI, 2023-03-13)
Multiple evidences suggest that mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease via the selective cell death of dopaminergic neurons, such as that which occurs after prolonged exposure ...
Specific phospholipid modulation by muscarinic signaling in a rat lesion model of Alzheimer's disease
(ACS. American Chemical Society, 2021-05-26)
La enfermedad de Alzheimer (EA) representa la causa más común de demencia en todo el mundo y se ha asociado sistemáticamente con la pérdida de neuronas colinérgicas del cerebro anterior basal (BFCNs) que conducen a una ...
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain
(John Wiley & Sons, 2015-04-10)
El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ...
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
(Springer Verlag, 2011-01-28)
[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ...
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
(Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ...
Effects of adult enriched environment on cognition, hippocampal- prefrontal plasticity and NMDAR subunit expression in MK-801- induced schizophrenia model
(Elsevier, 2019-05-01)
Schizophrenia is a mental disorder characterized by psychosis, negative symptoms and cognitive impairment. Cognitive deficits are enduring and represent the most disabling symptom but are currently poorly treated. N-methyl ...
Effects of galanin subchronic treatment on memory and muscarinic receptors.
(Elsevier, 2015-05-07)
Las vías colinérgicas, que se originan en el prosencéfalo basal y son responsables del control de diferentes procesos cognitivos como el aprendizaje y la memoria también están reguladas por algunos neuropéptidos. Uno de ...
In vitro pharmacodynamic modelling of anidulafungin against Candida spp.
(Elsevier, 2016-03)
[ES] El objetivo de este estudio fue ajustar los datos estáticos de muerte temporal in vitro de anidulafungina de nueve cepas de Candida con un modelo farmacodinámico (PD) para describir la actividad antifúngica de este ...