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Now showing items 161-166 of 166
Maternal Immune Activation Induces Cortical Catecholaminergic Hypofunction and Cognitive Impairments in Offspring
(Springer Nature, 2023)
Background
Impairment of specific cognitive domains in schizophrenia has been associated with prefrontal cortex (PFC) catecholaminergic deficits. Among other factors, prenatal exposure to infections represents an ...
Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
(Springer Nature, 2023)
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including ...
Inhibition of rat locus coeruleus neurons by prostaglandin E2 EP3 receptors: pharmacological characterization ex vivo
(Frontiers Media, 2023-11)
Prostaglandin E2 (PGE2) is an inflammatory mediator synthesized by the brain constitutive cyclooxygenase enzyme. PGE2 binds to G protein-coupled EP1-4 receptors (EP1 to Gq, EP2,4 to Gs, and EP3 to Gi/o). EP2, EP3 and EP4 ...
Efficacy of the combination of amphotericin B and echinocandins against Candida auris in vitro and in the Caenorhabditis elegans host model
(American Society of Microbiology, 2024-01)
The multidrug-resistant Candida auris is a global health emergency, being responsible for outbreaks of invasive candidiasis worldwide. Limited effective therapeutic options make it difficult to treat this emerging pathogen. ...
Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
(Nature, 2024-02)
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2R and mGlu3R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3R ligands in clinical trials. ...
Frontal Cortex Lipid alterations During the Onset of Alzheimer's Disease
(IOS Press, 2024-03-30)
Antecedentes: La enfermedad de Alzheimer (EA) esporádica es un trastorno neurodegenerativo de etiología desconocida. La EA familiar está asociada a mutaciones genéticas específicas. Una característica común de estas formas ...