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Cyclotryptophan Mycotoxins: Short Synthesis of the Desymmetrized meso-Chimonantine Core of Leptosin C
(Georg Thieme, 2016-12-01)
The desymmetrized meso-chimonantine core of leptosin C was prepared in a short stereoselective convergent sequence in 5 steps as the longest linear path from methyl l-tryptophan hydrochloride as starting material. The key ...
Synthesis of β-Hydroxy α-Amino Acids Through Brønsted Base-Catalyzed syn-Selective Direct Aldol Reaction of Schiff Bases of Glycine o-Nitroanilide
(ACS, 2021-05-16)
Here we report the highly enantio- and syn-selective synthesis of β-hydroxy α-amino acids from glycine imine derivatives under Brønsted base (BB) catalysis. The key of this approach is the use of benzophenone-derived imine ...
Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases
(Beilstein-Institut, 2016-10-28)
This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could ...
Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines
(MDPI, 2023-12-22)
In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those currently used. These disadvantages ...
Strain-induced effects in the electronic and spin properties of a monolayer of ferromagnetic GdAg 2
(Royal Society of Chemistry, 2016)
We report on the structural, electronic and magnetic properties of a monolayer of GdAg2, forming a moire pattern on Ag(111). Combining scanning tunneling microscopy and ab initio spin-polarized calculations, we show that ...
Fluorescent bicolour sensor for low-background neutrinoless double β decay experiments
(Nature, 2020-06-22)
Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles1. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is ...
Surface engineering of transaminases to tailor protein immobilization on microreactors
(2023-10-30)
El trabajo aquí presentado proporciona nuevas herramientas para optimizar nuevos biocatalizadores heterogéneos, abriendo un nuevo camino para el control racional de la orientación de las enzimas. Además, introdujimos un ...
DoE-driven development of an organocatalytic enantioselective addition of acetaldehyde to nitrostyrenes in water
(Wiley-VCH, 2022-03-01)
Moving from organic solvents to water is not always an easy task, especially when a lot of variables need to be screened. The development of an enantioselective enamine-catalysed Michael addition of acetaldehyde to ...
Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives
(Elsevier, 2018-09-15)
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. ...
Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiproliferatives
(Elsevier, 2020-04-03)
The topoisomerase I enzymatic inhibition of hybrid quinolino [4,3-b] (Siegel et al., 2013; Antony et al., 2003) [1,5]naphthyridines and quinolino [4,3-b] (Siegel et al., 2013; Antony et al., 2003) [1,5]naphthyridin-6(5H)-ones ...