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Beta-Hydroxyimino Phosphorus Derivatives. An Efficient Tool in Organic Synthesis
(Bentham Science Publishers, 2011)
[EN] The purpose of this review article is to illustrate synthetic aspects of functionalized phosphorus derivatives containing an oximo moiety at the beta-position. First section will be focused on the synthesis of phosphine ...
Adición conjugada asimétrica de equivalentes umpolung de acilo y carboxilo : auxiliares quirales vs organocatálisis
(2012-07-04)
En el trabajo de investigación que se recoge en la presente memoria se ha
estudiado la adición conjugada asimétrica de equivalentes sintéticos de aniones
acilo y carboxilo. Para dicho fin, han sido dos las estrategias ...
Computational Methods Applied to Transition Metal Catalysis and Pericyclic Reactions
(2020-07-10)
La presente tesis consiste en una serie de estudios realizados en el marco de la química computacional. La teoría del funcional de la densidad ha sido aplicada para la simulación de diversas reacciones químicas. Mediante ...
Modeling Antibacterial Activity with Machine Learning and Fusion of Chemical Structure Information with Microorganism Metabolic Networks
(American Chemical Society, 2019-02-25)
Predicting the activity of new chemical compounds over pathogenic microorganisms with different metabolic reaction networks (MRNs) is an important goal due to the different susceptibility to antibiotics. The ChEMBL database ...
Organocatalytic Enantioselective alpha-Nitrogenation of alpha,alpha- Disubstituted Aldehydes in the Absence of a Solvent
(American Chemical Society, 2022-10)
A highly efficient enantioselective alpha-nitrogenation method of alpha,alpha-disubstituted aldehydes with azodicarboxylates promoted by a chiral carbamate-monoprotected cyclohexa-1,2diamine as organocatalyst has been ...
Application of 1,3-Dipolar Reactions between Azomethine Ylides and Alkenes to the Synthesis of Catalysts and Biologically Active Compounds
(Wiley, 2018-11-25)
The (3+2) cycloaddition between azomethine ylides and alkenes is an efficient, convergent and stereocontrolled method for the synthesis of unnatural pyrrolidine and proline scaffolds. In this review, the application of ...
Higher-Order Electrocyclizations in Biological and Synthetic Processes
(Wiley, 2023-11)
In general, electrocyclizations follow the Woodward-Hoffmann's rules of conservation of orbital symmetry. These rules have been extensively verified in low-order processes, both in thermal and photochemical reactions, up ...
Chiral self-recognition in a bispericyclic cyclodimerisation reaction of 1-azadienes
(RSC, 2023-10)
Hermaphroditism of molecules: as in nature some species behave as male or female depending on the environment, herein we report a bispericyclic dimerisation of cyclic 1-azadienes where a molecule can behave as either diene ...
Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction—Applications as Antiproliferative Agents
(MDPI, 2022)
[EN] A study on the reactivity of 3-amino α,β-unsaturated γ-lactam derivatives obtained from a multicomponent reaction is presented. Key features of the substrates are the presence of an endocyclic α,β-unsaturated amide ...
Dynamic Nucleophilic Aromatic Substitution of Tetrazines
(Wiley, 2021-08-23)
A dynamic nucleophilic aromatic substitution of tetrazines (SNTz) is presented herein. It combines all the advantages of dynamic covalent chemistry with the versatility of the tetrazine moiety. Indeed, libraries of compounds ...