Search
Now showing items 421-430 of 502
Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las Encefalopatías Espongiformes Transmisibles humanas
(2020-09-11)
Las Encefalopatías Espongiformes Transmisibles (EET) son un conjunto de desórdenes neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo agente causante es una isoforma anormalmente plegada ...
Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging
(MDPI, 2023-10-10)
The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered significant attention in recent years due ...
Expression regulation and comparative interactome study of ANKRD55, a multiple sclerosis risk modulator
(2023-10-06)
La esclerosis múltiple (EM) es una enfermedad neurodegenerativa y autoinmune que a día de hoy no tiene cura. Se trata de una patología compleja que surge por una combinación de factores genéticos y ambientales. El objetivo ...
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
(2021-05-21)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...
Functional analysis of ankrd55, a multiple sclerosis risk gene with unknown function.
(2019-01-14)
El objetivo de este trabajo consiste en la caracterización de ANKRD55, un gen de función desconocida asociado a la esclerosis múltiple (EM). Para ello, por un lado, se realizó un análisis basado en DNA y expresión génica ...
Smooth muscle cell characterization and transcriptomic analysis in human carotid atherosclerotic plaques
(2018-10-19)
Las enfermedades cardiovasculares (CV) son una de las causas más importantes de discapacidad y muerte prematura en todo el mundo. Una de las causas subyacentes de las CV es la aterosclerosis. La aterosclerosis de carótida ...
Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease
(Public Library Science 15(6) : (2019) // Article ID e1008180, 2019-06-06)
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and neuronal dysfunction. Although the majority of patients do not present familial aggregation, Mendelian forms ...
Interactome of the Autoimmune Risk Protein ANKRD55
(Frontiers Media, 2019-09-18)
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of ...
A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation
(Biomed Central, 2012-01-17)
Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...
Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition
(MDPI, 2018-03)
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that ...