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dc.contributor.authorMartínez Malax-Echevarría, Irati ORCID
dc.contributor.authorMuts, Rudy
dc.contributor.authorVan Dijk, Linda
dc.contributor.authorParker, Craig T.
dc.contributor.authorMiller, William G.
dc.contributor.authorHuynh, Steven
dc.contributor.authorGaastra, Wim
dc.contributor.authorVan Putten, Jos P. M.
dc.contributor.authorFernández Astorga, Aurora ORCID
dc.contributor.authorWösten, Marc M. S. M.
dc.date.accessioned2013-01-17T19:15:29Z
dc.date.available2013-01-17T19:15:29Z
dc.date.issued2012-09-18
dc.identifier.citationPLoS ONE 7(9) : (2012) // e44796es
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/9216
dc.description11 p.es
dc.description.abstractThe extracytoplasmic function (ECF) σ factors are fundamental for bacterial adaptation to distinct environments and for survival under different stress conditions. The emerging pathogen Arcobacter butzleri possesses seven putative pairs of σ/anti-σ factors belonging to the ECF family. Here, we report the identification of the genes regulated by five out of the seven A. butzleri ECF σ factors. Three of the ECF σ factors play an apparent role in transport, energy generation and the maintenance of redox balance. Several genes like the nap, sox and tct genes are regulated by more than one ECF σ factor, indicating that the A. butzleri ECF σ factors form a network of overlapping regulons. In contrast to other eubacteria, these A. butzleri ECF regulons appear to primarily regulate responses to changing environments in order to meet metabolic needs instead of an obvious role in stress adaptation.es
dc.description.sponsorshipThis work was supported in part by the Basque Government (IT-528-10) through a Predoctoral Fellowship of the Basque Government for the Training of Researches (BF106.85); by a parallel incentive within the Predoctoral Fellowship of the Basque Government for short stays in different Research Centers (EC-2009-1-4); and by a European Molecular Biology Organization (EMBO) Short Term Fellowship (ASTF29-2010) to IMM. This work was also supported by a fellowship of Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO-Vidi) grant 917.66.330 to MMSMW and by funds from US Department of Agriculture Current Research Information System (USDA-CRIS) project 5325-42000-047-00D. No additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectcomponent systemes
dc.subjectescherichia colies
dc.subjectnonhuman primatees
dc.subjectstress-responsees
dc.subjectcampylobactees
dc.subjectsusceptibilityes
dc.subjectprevalencees
dc.subjecttransportes
dc.subjectabortionses
dc.subjectbacteriaes
dc.titleRegulation of Energy Metabolism by the Extracytoplasmic Function (ECF) σ Factors of Arcobacter butzleries
dc.title.alternativeRegulation of Energy Metabolism by the Extracytoplasmic Function (ECF) sigma Factors of Arcobacter butzleri
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0044796es
dc.identifier.doi10.1371/journal.pone.0044796
dc.departamentoesInmunología, microbiología y parasitologíaes_ES
dc.departamentoeuImmunologia, mikrobiologia eta parasitologiaes_ES
dc.subject.categoriaAGRICULTURAL AND BIOLOGICAL SCIENCES
dc.subject.categoriaMEDICINE
dc.subject.categoriaBIOCHEMISTRY AND MOLECULAR BIOLOGY


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