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dc.contributor.authorSánchez Ovejero, Carlos
dc.contributor.authorBenito López, Fernando ORCID
dc.contributor.authorDíez García, Paula
dc.contributor.authorCasulli, Adriano
dc.contributor.authorSiles Lucas, Mar
dc.contributor.authorFuentes García, Manuel
dc.contributor.authorManzano Román, Raúl
dc.date.accessioned2016-10-04T14:47:13Z
dc.date.available2016-10-04T14:47:13Z
dc.date.issued2016-03-16
dc.identifier.citationJournal of Proteomics 136 : 145-156 (2016)es
dc.identifier.issn1874-3919
dc.identifier.urihttp://hdl.handle.net/10810/19066
dc.description.abstract[EN] Parasitic diseases have a great impact in human and animal health. The gold standard for the diagnosis of the majority of parasitic infections is still conventional microscopy, which presents important limitations in terms of sensitivity and specificity and commonly requires highly trained technicians. More accurate molecular-based diagnostic tools are needed for the implementation of early detection, effective treatments and massive screenings with high-throughput capacities. In this respect, sensitive and affordable devices could greatly impact on sustainable control programmes which exist against parasitic diseases, especially in low income settings. Proteomics and nanotechnology approaches are valuable tools for sensing pathogens and host alteration signatures within micro fluidic detection platforms. These new devices might provide novel solutions to fight parasitic diseases. Newly described specific parasite derived products with immune-modulatory properties have been postulated as the best candidates for the early and accurate detection of parasitic infections as well as for the blockage of parasite development. This review provides the most recent methodological and technological advances with great potential for biosensing parasites in their hosts, showing the newest opportunities offered by modern “-omics” and platforms for parasite detection and control.es
dc.description.sponsorshipThis research was funded by HERACLES project (http://www.heracles-fp7.eu/) under the European Commission Seventh Framework Programme (FP7-602051). FBL acknowledges the support of the Ramón y Cajal programme (RYC-2012-10796, Ministerio de Economía y Competitividad). We also gratefully acknowledge financial support from the Carlos III Health Institute of Spain (ISCIII, FIS PI14/01538 and FIS PI12/00624), Fondos FEDER (EU) and Junta Castilla-León BIO/SA07/15. The Proteomics Unit belongs to ProteoRed, PRB2-ISCIII, supported by grant PT13/0001(ISCIII-Fondos FEDER). P.D. is supported by a JCYL-EDU/346/2013 Ph.D. scholarship.es
dc.language.isoenges
dc.publisherElsevieres
dc.relationeu-repo/grantAgreement/EC/FP7/602051es
dc.relationinfo:eu-repo/grantAgreement/MINECO/RYC-2012-10796
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectdetection platformses
dc.subjectdiagnosises
dc.subjectproteomicses
dc.subjectparasitic diseaseses
dc.subjectsensorses
dc.subjectmicrofluidicses
dc.titleSensing parasites: proteomic and advanced bio-detection alternativeses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2016 Elsevier B.V. All rights reserved.es
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1874391916300057es
dc.identifier.doi10.1016/j.jprot.2015.12.030
dc.departamentoesQuímica analíticaes_ES
dc.departamentoeuKimika analitikoaes_ES
dc.subject.categoriaBIOCHEMISTRY AND MOLECULAR BIOLOGY
dc.subject.categoriaBIOPHYSICS


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