Browsing Artículos by Author "Etxebarria, Nestor"
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A clean up step of fat content previous to trace metal characterization in mussel tissues by inductively coupled plasma mass spectrometry
Raposo Fernández, Juan Carlos; Villanueva Saracho, Unai; Bartolomé Moro, Luis Javier; Olivares Zabalandicoechea, Maitane; Carrero Hernández, José Antonio; Sarmiento Romayor, Alfredo; Etxebarria Loizate, Nestor; Madariaga Mota, Juan Manuel (Elsevier, 2011-05-24)Inductively coupled plasma mass spectrometry analysis of trace and major elements of mussel tissues can be quickly and accurately analyzed after cleaning up the interfering fat content before the sample is digested in a ... -
Antioxidant activities and selenogene transcription in the european sea bass (Dicentrarchus labrax) liver depend, in a non-linear manner, on the Se/Hg molar tatio of the feeds
Espino, Marinelle; Eguiraun Martínez, Harkaitz; Diaz de Cerio Arruabarrena, Oihane ; Carrero Hernández, José Antonio; Etxebarria Loizate, Nestor; Martínez Galarza, María Iciar (Springer Nature ; Humana Press, 2021-07-01)[EN] Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively affected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription ... -
Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases
Arriortua, Oihane ; Garaio, Eneko; Herrero de la Parte, Borja ; Insausti Peña, María Teresa; Lezama Diago, Luis María; Plazaola Muguruza, Fernando ; García Martínez, José Angel; Aizpurua Iparraguirre, Jesús María ; Sagartzazu Aizpurua, Maialen; Irazola Duñabeitia, Mireia; Etxebarria Loizate, Nestor; García Alonso, Ignacio; Saiz López, Alberto; Echevarría Uraga, Jose Javier (Beilstein-Institut, 2016-10-28)This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could ... -
Application of a Biological Multilevel Response Approach in the Copepod Acartia Tonsa for Toxicity Testing of Three Oil Water Accommodated Fractions
Hafez, Tamer; Bilbao Alemany, Dennis; Etxebarria Loizate, Nestor; Duran, Robert; Ortiz Zarragoitia, Maren (Elsevier, 2021-06-01)Abstract Copepods play a critical role in the marine food webs, being a food source for marine organisms. In this study, we investigated the toxic effects of Water Accommodated Fractions (WAFs) from three types of oil: ... -
Biochemical and Metabolomic Changes after Electromagnetic Hyperthermia Exposure to Treat Colorectal Cancer Liver Implants in Rats
Herrero de la Parte, Borja; Irazola Duñabeitia, Mireia; Pérez Muñoz, Jorge; Rodrigo Arrizabalaga, Irati; Iturrizaga Correcher, Sira; Mar Medina, Carmen; Castro Ortiz de Pinedo, Kepa ; Etxebarria Loizate, Nestor; Plazaola Muguruza, Fernando ; García Martínez, José Angel; García-Alonso Montoya, Ignacio ; Echevarría Uraga, José Javier (MDPI, 2021-05-17)Background: Hyperthermia (HT) therapy still remains relatively unknown, in terms of both its biological and therapeutic effects. This work aims to analyze the effects of exposure to HT, such as that required in anti-tumor ... -
Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients
Ibarra Lecue, Inés ; Unzueta Larrinaga, Paula; Barrena Barbadillo, Rocío; Villate Uribe, Aitor; Horrillo Furundarena, Igor ; Mendivil, Begoña; Landabaso, Miguel A.; Meana Martínez, José Javier ; Etxebarria Loizate, Nestor; Callado Hernando, Luis Felipe ; Urigüen Echeverría, Leyre (Wiley, 2022-11)Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5-HT2AR) have been involved in psychosis and, like ... -
Characterization of the contamination fingerprint of wastewater treatment plant effluents in the Henares River Basin (central Spain) based on target and suspect screening analysis
López Herguedas, Naroa; González Gaya, Belén; Castelblanco Boyacá, Nicolás; Rico, A.; Etxebarria Loizate, Nestor; Olivares Zabalandicoechea, Maitane; Prieto Sobrino, Ailette; Zuloaga Zubieta, Olatz (Elsevier, 2022-02-01)The interest in contaminants of emerging concern (CECs) has increased lately due to their continued emission and potential ecotoxicological hazards. Wastewater treatment plants (WWTPs) are generally not capable of eliminating ... -
Development and evaluation of a comprehensive workflow for suspect screening of exposome-related xenobiotics and phase II metabolites in diverse human biofluids
Musatadi Larrucea, Mikel; Baciero Hernández, Inés; Prieto Sobrino, Ailette; Olivares Zabalandikoetxea, Maitane; Etxebarria Loizate, Nestor; Zuloaga Zubieta, Olatz (Elsevier, 2024-01-13)Suspect and non-target screening (SNTS) methods are being promoted in order to decode the human exposome since a wide chemical space can be analysed in a diversity of human biofluids. However, SNTS approaches in the ... -
Development of an analytical method for the simultaneous determination of 50 semi-volatile organic contaminants in wastewaters
Mijangos Treviño, Leire; Bilbao Alemany, Dennis; López Herguedas, Naroa; Olivares Zabalandicoechea, Maitane; Zuloaga Zubieta, Olatz; Etxebarria Loizate, Nestor; Ortueta Mateo, Natalia; Prieto Sobrino, Ailette (Elsevier, 2023-06-11)This work describes the development of a robust analytical methodology for the simultaneous determination of 50 semi-volatile organic compounds (SVOCs) in wastewater effluent samples by solid-phase extraction (SPE) followed ... -
Effect-directed analysis of a hospital effluent sample using A-YES for the identification of endocrine disrupting compounds
López Herguedas, Naroa; González Gaya, Belén; Cano, Alicia; Álvarez Mora, Iker; Mijangos Treviño, Leire; Etxebarria Loizate, Nestor; Zuloaga Zubieta, Olatz; Olivares Zabalandicoechea, Maitane; Prieto Sobrino, Ailette (Elsevier, 2022-12)An effect-directed analysis (EDA) approach was used to identify the compounds responsible for endocrine disruption in a hospital effluent (Basque Country). In order to facilitate the identification of the potentially toxic ... -
Evaluating membrane bioreactor treatment for the elimination of emerging contaminants using different analytical methods
López Herguedas, Naroa; Irazola Duñabeitia, Mireia; Álvarez Mora, Iker; Mijangos Treviño, Leire; Bilbao Alemany, Dennis; Etxebarria Loizate, Nestor; Zuloaga Zubieta, Olatz; Olivares Zabalandicoechea, Maitane; Prieto Sobrino, Ailette (Elsevier, 2023-10-22)Since wastewater treatment plants (WWTPs) were not originally designed to eliminate contaminants of emerging concern (CECs), alternative strategies like membrane bioreactor (MBR) technology are gaining importance in achieving ... -
Exploratory optimisation of a LC-HRMS based analytical method for untargeted metabolomic screening of Cannabis Sativa L. through Data Mining
San Nicolas Oruetxebarria, Markel; Villate Uribe, Aitor; Olivares Zabalandicoechea, Maitane; Etxebarria Loizate, Nestor; Zuloaga Zubieta, Olatz; Aizpurua Olaizola, Oier; Usobiaga Epelde, Aresatz (Elsevier, 2023-10)Background Recent increase in public acceptance of cannabis as a natural medical alternative for certain neurological pathologies has led to its approval in different regions of the world. However, due to its previous ... -
Gametogenesis-Related Fluctuations in Ovothiol Levels in the Mantle of Mussels from Different Estuaries: Fighting Oxidative Stress for Spawning in Polluted Waters
Diaz de Cerio Arruabarrena, Oihane ; Reina, Lander; Squatrito, Valeria; Etxebarria Loizate, Nestor; González Gaya, Belén; Cancio Uriarte, Ibon (MDPI, 2020-02-28)Reactive oxygen species present a challenge for marine organisms releasing gametes into the water. Thiol-containing molecules protect cells against oxidative stress, and ovothiol (OSH), an antioxidant-reducing mercaptohistidine, ... -
High microbiome and metabolome diversification in coexisting sponges with different bio-ecological traits
Mazzella, Valeria; Dell’Anno, Antonio; Etxebarria Loizate, Nestor; González Gaya, Belén; Nuzzo, Genoveffa; Fontana, Angelo; Núñez Pons, Laura (Nature, 2024)Marine Porifera host diverse microbial communities, which influence host metabolism and fitness. However, functional relationships between sponge microbiomes and metabolic signatures are poorly understood. We integrate ... -
Influence of dispersant application on the toxicity to sea urchin embryos of crude and bunker oils representative of prospective oil spill threats in Arctic and Sub-Arctic seas
De Miguel Jiménez, Laura ; Etxebarria Loizate, Nestor; Lecube Iturrioz, Xabier; Izaguirre Aramayona, Urtzi; Marigómez Allende, Juan Antonio (Elsevier, 2021-09-09)This study deals with the toxicity assessment of crude and bunker oils representative of prospective oil spill threats in Arctic and Sub-Arctic seas (NNA: Naphthenic North-Atlantic crude oil; MGO: Marine Gas Oil; IFO: ... -
Influence of season-depending ecological variables on biomarker baseline levels in mussels (Mytilus trossulus) from two Baltic Sea subregions
Benito Fernández, Denis ; Ahvo, Aino; Nuutinen, Jari; Bilbao Alemany, Dennis; Sáenz Aguirre, Jon ; Etxebarria Loizate, Nestor; Lecube Iturrioz, Xabier; Izaguirre Aramayona, Urtzi; Lehtonen, Kari K.; Marigómez Allende, Juan Antonio ; Zaldibar Aramburu, Beñat ; Soto López, Manuel (Science Direct, 2019-06-26)For reliable mussel monitoring programmes based on biomarkers, regionally relevant reference values and their natural variability need to be known. The Baltic Sea exhibits high inter-regional and seasonal variability in ... -
Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
Blanco Rayón, Esther; Ziarrusta Intxaurtza, Haizea; Mijangos Treviño, Leire; Olivares Zabalandicoechea, Maitane; Zuloaga Zubieta, Olatz; Etxebarria Loizate, Nestor; Izaguirre Aramayona, Urtzi (Elsevier, 2021-11)[EN]Amitriptyline (AMI) is a commonly tricyclic antidepressant to treat depression, anxiety, and other conditions. Like many other pharmaceuticals, AMI and its by-products are incompletely removed during wastewater treatment ... -
Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
Unzueta Larrinaga, Paula; Barrena Barbadillo, Rocío; Ibarra Lecue, Inés ; Horrillo Furundarena, Igor ; Villate Uribe, Aitor; Recio Barbero, María; Meana Martínez, José Javier ; Díez Alarcia, Rebeca ; Mentxaka Solozabal, Oihane; Segarra Echevarria, Rafael; Etxebarria Loizate, Nestor; Callado Hernando, Luis Felipe ; Urigüen Echeverría, Leyre (Springer Nature, 2023)The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including ... -
Metabolomics to study the sublethal effects of diazepam and irbesartan on glass eels (Anguilla anguilla)
Álvarez Mora, Iker; Bolliet, Valérie; López Herguedas, Naroa; Olivares Zabalandicoechea, Maitane; Monperrus, Mathilde Elisabeth; Etxebarria Loizate, Nestor (Elsevier, 2023-06)Since glass eels are continuously exposed to contamination throughout their migratory journey in estuaries, to a certain extent the fall in the population of this endangered species might be attributed to this exposure, ... -
Multi-Target Analysis and Suspect Screening of Xenobiotics in Milk by UHPLC-HRMS/MS
Musatadi Larrucea, Mikel; González Gaya, Belén; Irazola Duñabeitia, Mireia; Prieto Sobrino, Ailette; Etxebarria Loizate, Nestor; Olivares Zabalandicoechea, Maitane; Zuloaga Zubieta, Olatz (MDPI, 2021-01-26)The development of suspect or non-target screening methods to detect xenobiotics in biological fluids is essential to properly understand the exposome and assess its adverse health effects on humans. In order to fulfil ...