BackBrowsing Artículos by Title
Now showing items 1200-1219 of 10327
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Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease
(Nature, 2024-01)Retinal thickness may serve as a biomarker in Parkinson’s disease (PD). In this prospective longitudinal study, we aimed to determine if PD patients present accelerated thinning rate in the parafoveal ganglion cell-inner ... -
Association of TYR SNP rs1042602 with Melanoma Risk and Prognosis
Sevilla Mambrilla, Arrate
; ; ; Izagirre Arribalzaga, Neskuts ; ; ; ; ; ; ; ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores ; Alonso Alegre, Santos (MDPI, 2022-12-01)
Cutaneous melanoma is the most aggressive of skin tumors. In order to discover new biomarkers that could help us improve prognostic prediction in melanoma patients, we have searched for germline DNA variants associated ... -
Associations Between Birth Size and Later Height From Infancy Through Adulthood: an Individual Based Pooled Analysis of 28 Twin Cohorts Participating in the Codatwins Project
Jelenkovic Moreno, Aline; Yokoyama, Yoshie; Sund, Reijo; Hur, Yoon-Mi; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas Sevenius; Ooki, Syuichi; Ullemar, Vilhelmina; Almqvisth, Catarina; Magnusson, Patrik K. E.; Saudino, Kimberly J.; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Nelson, Tracy L.; Whitfield, Keith E.; Knafo Noam, Ariel; Mankuta, David; Abramson, Lior; Cutler, Tessa L.; Hopper, John L.; Llewellyn, Clare H.; Fisher, Abigail; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Bjerregaard Andersen, Morten; Nielsen, Henning Beck; Sodemann, Morten; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Burt, S. Alexandra; Klump, Kelly L.; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Willemsen, Gonneke; Bartels, Meike; Van Beijsterveld, Catharina E. M.; Craig, Jeffrey M.; Saffery, Richard; Rasmussen, Finn; Tynelius, Per; Heikkila, Kauko; Pietilainen, Kirsi H.; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Haworth, Claire M. A.; Plomin, Robert; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato Ochoa, Esther Matilde; Tarnoki, Adam D.; Tarnoki, David L.; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Sung, Joohon; Loos, Ruth J. F.; Boomsma, Dorret I.; Sorensen, Thorkild I. A.; Kaprio, Jaakko; Silventoinen, Karri (Elsevier Ireland, 2018-05)
Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the ... -
Associations between Coping Strategies and Cyberhate Involvement: Evidence from Adolescents across Three World Regions
(MDPI, 2022)Cyberhate represents a risk to adolescents’ development and peaceful coexistence in democratic societies. Yet, not much is known about the relationship between adolescents’ ability to cope with cyberhate and their cyberhate ... -
Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex
; ; ; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (MDPI, 2019-11-08)
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals ... -
Associations between Well-Being State and Match External and Internal Load in Amateur Referees
Ozaeta Beaskoetxea, Eñaut; Yanci Irigoyen, Javier ; ; ; (MDPI, 2021-03-23)
The main aim of this paper was to examine the association between prematch well-being status with match internal and external load in field (FR) and assistant (AR) soccer referees. Twenty-three FR and 46 AR participated ... -
Associations of Maternal Cell-Phone Use During Pregnancy With Pregnancy Duration and Fetal Growth in 4 Birth Cohorts
(Oxford University Press, 2019-04-17)Results from studies evaluating potential effects of prenatal exposure to radio-frequency electromagnetic fields from cell phones on birth outcomes have been inconsistent. Using data on 55,507 pregnant women and their ... -
Associations of residential greenspace exposure and fetal growth across four areas in Spain
(Elsevier, 2022-11)An accumulating body of evidence has associated exposure to greenspace with improved birth outcomes, including higher birth weight and lower risk of low birth weight; however, evidence on such association with in-utero ... -
Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison
; ; Malaina Celada, Iker; ; Martínez Fernández, Luis ; Pérez-Yarza Pérez-Irezabal, Gorka ; Boyano López, María Dolores ; ; ; ; ; (Frontiers Media, 2021-07-19)
The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in a preliminary analysis, the emergence of conditioned behavior in some individual amoebae ... -
Astarloaren Discursos filosóficos: iturrak eta axiomak
Gómez López, Ricardo (IKER UMR 5478, 2004)
Astarloa's Discursos filosóficos is the most extensive and detailed apology of the Basque language as the first language of mankind. The text was finished in 1805 but the first edition was published in 1883. In this paper ... -
Astarloaren ekarpena euskal gramatikaren ikerketetan
Gómez López, Ricardo (Euskaltzaindia, 2002)
[EN] This paper explores a lesser-known aspect of Basque linguist Pablo Astarloa, namely, his contribution as grammarian. Astarloa is better known for his hypothesis that Basque language was humankind’s first language and, ... -
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
(2021-03)Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive ... -
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
Preman, Pranav; Alfonso Triguero, Maria; Alberdi Alfonso, Elena María; Verkhratsky, Alexei; Arranz Mendiguren, Amaia (MDPI, 2021-03-04)
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. ... -
Astrocytic Atrophy as a Pathological Feature of Parkinson's Disease with LRRK2 Mutation
Ramos González, Paula; Mato Santos, Susana; Chara Ventura, Juan Carlos; Verkhratsky, Alexei; ; Cavaliere, Fabio (Springer, 2021-03-30)
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased ... -
La asunción cumulativa de deuda: naturaleza y régimen
Castellanos Cámara, Sandra (Bercal, 2022-12-31)
[ES] Este trabajo tiene por objeto analizar la asunción cumulativa de deuda ajena, una construcción doctrinal y jurisprudencial que toma como punto de partida la asunción de deuda liberatoria y descansa sobre la base del ... -
Asymmetric Dual Enamine Catalysis/Hydrogen Bonding Activation
; Prieto Aretxabaleta, Liher; Uria Pujana, Uxue ; Carrillo Fernández, María Luisa ; Vicario Hernando, José Luis (MDPI, 2023-07-11)
Asymmetric enamine base activation of carbonyl compounds is a well-known and widely used strategy for providing functionalization of organic compounds in an efficient way. The use of solely organic substances, which in ... -
Asymmetric Mannich reactions of (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines with yne nucleophiles
Li, Ziyi; Wang, Li; Huang, Yunqi; Mei, Haibo; Konno, Hiroyuki; Moriwaki, Hiroki; Soloshonok, Vadym Anatolievch; Han, Jianlin (Beilstein-Institut, 2020-10-29)
In the present work, arylethynes were studied as new C-nucleophiles in the asymmetric Mannich addition reactions with (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. The reactions were conducted under operationally ... -
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
Han, Jianlin; ; Fustero, Santos ; ; Soloshonok, Vadym Anatolievch ; Sorochinsky, Alexander (MDPI, 2022)
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, ... -
Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists
; Prieto Aretxabaleta, Liher; (MDPI, 2022-12-29)
Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime. The number of chiral, non-racemic ... -
Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent
Zou, Yupiao; Takeda, Ryosuke; Han, Jianlin; Konno, Hiroyuki; Moriwaki, Hiroki; Abe, Hidenori; Izawa, Kunisuke; Soloshonok, Vadym Anatolievch (Wiley, 2021-06-07)
Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally diverse tailor-made amino acids. In this manuscript, asymmetric alkylation ...