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Mutations in the ‘Fingers’ subdomain of the deubiquitinase USP1 modulate its function and activity
(FEBS Press, 2016-01-13)
Ubiquitin-specific protease (USP)1 is a member of the USP family of deubiquitinating enzymes. Efficient USP1 activity requires binding to its cofactor USP1-associated factor 1 (UAF1), and the USP1-UAF1 deubiquitinase complex ...
Growth and Physiological Performance in Growth Phenotypes of the Carpet Shell Clam (Ruditapes decussatus) Fed Diets of Variable Lipid/Carbohydrate Ratios
(Hindawi, 2023-08-12)
Mixed suspensions of phytoplankton and yeast cells in different proportions were designed to achieve diets with a range of
variation (0.6–2.2) in the ratio of lipid to carbohydrate while maintaining protein content constant. ...
Stoichiometry of growth under variable scenarios of nutrient limitation: Differential homeostasis of body composition among growth phenotypes of the Manila clam
(Elsevier, 2024-02-07)
Fast- and slow-growing phenotypes from two separate breeding families of the Manila clam (Ruditapes philippinarum)
were alternatively fed two monoalgal diets with high and low N content (C:N ratios of 4.9 and 13.5,
res ...
High Throughput Fluorescence-Based In Vitro Experimental Platform for the Identification of Effective Therapies to Overcome Tumour Microenvironment-Mediated Drug Resistance in AML
(MDPI, 2023-03-27)
The interactions between Acute Myeloid Leukaemia (AML) leukemic stem cells and the bone marrow (BM) microenvironment play a critical role during AML progression and resistance to drug treatments. Therefore, the identification ...
Elemental C and N balances evidence stoichiometric adjustments to dietary protein content in growth phenotypes of the Manila clam (Ruditapes philippinarum)
(Elsevier, 2022-03-24)
Juveniles from two separately bred families of the Manila clam Ruditapes philippinarum were used to constitute
fast (F)- and slow (S)-growing groups by size segregation. The growth phenotypes that resulted from these ...
From classical to nonparametric growth models: Towards comprehensive modelling of mussel growth patterns
(Elsevier, 2017-03-18)
Understanding biological processes, such as growth, is crucial to development management and sustainability plans for bivalve populations. Von Bertalanffy and Gompertz models have been commonly used to fit bivalve growth. ...
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
(Frontiers Media, 2023-02)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ...
LncRNA ARGI Contributes to Virus-Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN-Stimulated Genes
(Wiley, 2023-09)
Type 1 diabetes (T1D) is a complex autoimmune disease that develops in genetically susceptible individuals. Most T1D-associated single nucleotide polymorphisms (SNPs) are located in non-coding regions of the human genome. ...
Improving the mechanical and biological functions of cell sheet constructs: The interplay of human-derived periodontal ligament stem cells, endothelial cells and plasma rich in growth factors
(Elsevier, 2024-05)
Objective
The aim of this study was to produce and characterize triple-layered cell sheet constructs with varying cell compositions combined or not with the fibrin membrane scaffold obtained by the technology of Plasma ...
Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
(Oxford University Press, 2017-10)
Background: There is evidence that birthweight is positively associated with body mass
index (BMI) in later life, but it remains unclear whether this is explained by genetic factors
or the intrauterine environment. We ...