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Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes
(ACS Publications, 2016-02-24)
Selective Pd-catalyzed C(sp2)–H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C–H functionalization events, which preferentially occur at the activated heterocyclic C–H bond, ...
Site-Selective Aqueous C–H Acylation of Tyrosine-Containing Oligopeptides with Aldehydes
(RSC, 2020-10-06)
The development of useful synthetic tools to label amino acids within a peptide framework for the ultimate modification of proteins in a late-stage fashion is a challenging task of utmost importance within chemical biology. ...
Site-Selective Trifluoromethylation Reactions of Oligopeptides
(Wiley, 2020-06-08)
Site-selective chemical modifications that target proteinogenic amino acid residues complement the methods entailing genetic manipulation, thereby allowing straightforward and rapid access to engineered proteins. The ...
Metal-catalyzed C–H functionalization processes upon “click”-triazole assistance
(Wiley, 2018-08-24)
The functionalization of otherwise unreactive C–H bonds holds great promise for reducing the reliance on existing functional groups while improving energy efficiency and atom-economy. One of the most powerful strategies ...
Pd-catalyzed site-selective C(sp(2))-H radical acylation of phenylalanine containing peptides with aldehydes
(Royal Society of Chemistry, 2019-08-07)
The site-selective functionalization of C-H bonds within a peptide framework remains a challenging task of prime synthetic importance. Herein, the first Pd-catalyzed delta-C(sp(2))-H acylation of Phe containing peptides ...
Pd-catalyzed site-selective C(sp2)–H radical acylation of phenylalanine containing peptides with aldehydes
(Royal Society of Chemistry, 2019-10-14)
The site-selective functionalization of C-H bonds within a peptide framework remains a challenging task of prime synthetic importance. Herein, the first Pd-catalyzed delta-C(sp(2))-H acylation of Phe containing peptides ...
Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor
(Beilstein Institut, 2011-07)
The synthesis of a GSK 2(nd) generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between ...
Synthetic scope and DFT analysis of the chiral binap-gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes
(Beilstein Institut, 2013-11)
he 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(S-a)-Binap.AuTFA](2). The alanine-derived oxazolone only reacts with tert-butyl ...
Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides
(Georg Thieme Verlag, 2018-06-25)
The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic ...
Iron-Catalyzed C(sp3)−H Functionalization of N,N-Dimethylanilines with Isocyanides
(Royal Society of Chemistry, 2018-01-22)
An efficient ligand-free Fe-catalyzed oxidative Ugi-type reaction toward the assembly of α-amino amides and short peptides is described. The reaction proceeds through the α-C(sp3)−H oxidation of N,N-dimethylanilines and ...