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Now showing items 1581-1590 of 2620
Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA
(MDPI, 2020-12-18)
The development of safe and effective nucleic acid delivery systems remains a challenge, with solid lipid nanoparticle (SLN)-based vectors as one of the most studied systems. In this work, different SLNs were developed, ...
Evaluation of the Radar Speed Cameras and Panels Indicating the Vehicles’ Speed as Traffic Calming Measures (TCM) in Short Length Urban Areas Located along Rural Roads
(MDPI, 2021-12-05)
Traffic calming measures (TCMs) are implemented in urban areas to reduce vehicles’ speed and, generally speaking, results are obtained. However, speed is still a problem in rural roads crossing small villages without ...
Constellation Loss: Improving the Efficiency of Deep Metric Learning Loss Functions for the Optimal Embedding of Histopathological Images
(Wolters Kluwer, 2020-11-26)
Background: Deep learning diagnostic algorithms are proving comparable results with human experts in a wide variety of tasks, and they still require a huge amount of well-annotated data for training, which is often non ...
Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer
(MDPI, 2021-06-21)
BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed ...
A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
(MDPI, 2021-05-03)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ...
Latitude Dictates Plant Diversity Effects on Instream Decomposition
(American Association for the Advancement of Science, 2021-03)
Running waters contribute substantially to global carbon fluxes through decomposition of terrestrial plant litter by aquatic microorganisms and detritivores. Diversity of this litter may influence instream decomposition ...
Soft-Sensor for Class Prediction of the Percentage of Pentanes in Butane at a Debutanizer Column
(MDPI, 2021-06-09)
Refineries are complex industrial systems that transform crude oil into more valuable subproducts. Due to the advances in sensors, easily measurable variables are continuously monitored and several data-driven soft-sensors ...
Immigrant students’ minority language learning: an analysis of language ideologies
(Routledge Journals, Taylor & Francis, 2021-04-03)
This paper focuses on language ideologies in relation to identity in Basque secondary education, in a context where the teaching of a minority language is part of the curriculum. More precisely, it addresses the views held ...
α-Galactosidase A Augmentation by Non-Viral Gene Therapy: Evaluation in Fabry Disease Mice
(MDPI, 2021-05-21)
Fabry disease (FD) is a monogenic X-linked lysosomal storage disorder caused by a deficiency in the lysosomal enzyme α-Galactosidase A (α-Gal A). It is a good candidate to be treated with gene therapy, in which moderately ...
Development of Kraft Lignin Chemically Modified as a Novel Crosslinking Agent for the Synthesis of Active Hydrogels
(MDPI, 2021-04-28)
In this research a chemical modification of kraft lignin was carried out using a basic nucleophilic substitution reaction (NSA) in order to functionalize it as a novel crosslinking agent for the synthesis of active hydrogels. ...