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Now showing items 3481-3490 of 4794
A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation
(Biomed Central, 2012-01-17)
Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...
Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition
(MDPI, 2018-03)
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that ...
Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response
(Frontiers Media, 2018-12-14)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. Two of these, IL-22BPi2 and IL-22BPi3, are capable of neutralizing the ...
A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation
(Public Library of Science, 2013-12-11)
Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...
Fine mapping and functional analysis of the multiple sclerosis risk gene CD6
(Public Library of Science, 2013)
CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single
nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger ...
Behaviour of Rh supported on hydroxyapatite catalysts in partial oxidation and steam reforming of methane: On the role of the speciation of the Rh particles
(Elsevier, 2018-03-04)
Rh/hydroxyapatite samples were prepared by impregnation and investigated for the partial oxidation (POM) and steam reforming (SRM) of methane. The catalysts were analysed by BET, XRD, DRS, XPS, H 2 -TPR, TEM, H2 chemisorption, ...
Augmented Renal Clearance in Critically Ill Patients: A Systematic Review
(Springer, 2018-02-13)
Background Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context.
Nevertheless, augmented renal clearance ...
Diferenciación socio-espacial urbana: mapa sintético de la estratificación de los barrios de Bilbao
(Universitat de Barcelona, 2018-11-01)
El objetivo de este trabajo es obtener una clasificación de los barrios de Bilbao (España) que permita apoyar la formulación y aplicación de las políticas urbanas. Para ello, se ha realizado una caracterización de los ...
Crisis y austeridad: amenaza para el empleo femenino en las regiones europeas
(Universidad Autónoma del Estado de México, 2018-03-20)
El objetivo del trabajo es explorar la relación entre las tasas de paro de mujeres y de hombres, y la variación en el empleo público a escala regional. Para ello se plantean diversos indicadores orientados al análisis ...
Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation
(Public Library of Science, 2013-02-19)
Background: Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited by inflammation mediates tissue damage.
Metho ...