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Wide Screening of Phage-Displayed Libraries Identifies Immune Targets in Planta
(PLoS ONE, 2013)
Microbe-Associated Molecular Patterns and virulence effectors are recognized by plants as a first step to mount a defence response against potential pathogens. This recognition involves a large family of extracellular ...
Kv7 Channels Can Function without Constitutive Calmodulin Tethering
(Public Library of Science, 2011-09-28)
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 ...
Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis
(Public Library Science, 2016-03-31)
The presence of endogenous opioid peptides in different testicular cell types has been extensively characterized and provides evidence for the participation of the opioid system in the regulation of testicular function. ...
Dipeptidyl-Peptidase IV Activity Is Correlated with Colorectal Cancer Prognosis
(Public Library Science, 2015-03-19)
Background
Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. Previous ...
TWEAK/Fn14 Signaling Is Required for Liver Regeneration after Partial Hepatectomy in Mice
(Public Library of Science, 2014-01)
Background & Aims: Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of ...
The Voltage-Gated Sodium Channel Na(v)1.8 Is Expressed in Human Sperm
(Public Library of Science, 2013-09)
The role of Na+ fluxes through voltage-gated sodium channels in the regulation of sperm cell function remains poorly understood. Previously, we reported that several genes encoding voltage-gated Na+ channels were expressed ...
On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis
(Public Library Science, 2014-10-10)
Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect ...
TWEAK/Fn14 Signaling Is Required for Liver Regeneration after Partial Hepatectomy in Mice
(Public Library Science, 2014-01-09)
Background & Aims: Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of ...
The E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice
(Public Library Science, 2014-11-14)
Increasing evidence links metabolic signals to cell proliferation, but the molecular wiring that connects the two core machineries remains largely unknown. E2Fs are master regulators of cellular proliferation. We have ...