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Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus
(Elsevier, 2019-04-22)
The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. ...
Tolkien: creador de la Tierra Media
(Sociedad Tolkien Colombia Orodruin, 2020-03)
Localization and Function of the Cannabinoid CB1 Receptor in the Anterolateral Bed Nucleus of the Stria Terminalis
(Public Library of Science, 2010-01-25)
Background: The bed nucleus of the stria terminalis (BNST) is involved in behaviors related to natural reward, drug addiction and stress. In spite of the emerging role of the endogenous cannabinoid (eCB) system in these ...
Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine
(Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
(2018-05-04)
The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ...
P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
(Frontiers Media, 2020-06-18)
Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and ...
An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial
(Frontiers Media, 2020)
Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable ...
Plastically-Induced Volume Deformation of Nanocrystalline α-Fe with a '110' Columnar Structure
(MDPI, 2020-12-07)
Volume changes accompanying the plastic deformation at 300 K of nanocrystalline samples of α-Fe with a columnar grain structure possessing a ⟨11¯0⟩
random fiber texture has been obtained from molecular dynamics (MD) ...
Study Of The Soluble Salts Formation In A Recently Restored House Of Pompeii By In-Situ Raman Spectroscopy
(Nature Publishing Group, 2018-01-25)
The walls and mural paintings of Pompeii exposed directly to the rainfalls are the most impacted in view of the observed decay. However, there are also wall paintings in protected rooms showing evidences of decaying. The ...
Multianalytical Approach to explain the darkening process of hematite pigment in paintings from ancient Pompeii after accelerated weathering experiments
(Royal Society of Chemistry, 2013-10-17)
[EN] In this paper, recently excavated fresco painting fragments from the House of Marcus Lucretius (Pompeii) and not exposed to the atmosphere since the eruption of the Mount Vesuvius were subjected to a controlled SO2 ...