Show simple item record

dc.contributor.authorBossion, Amaury
dc.contributor.authorJones, Gavin O.
dc.contributor.authorTaton, Daniel
dc.contributor.authorMecerreyes Molero, David
dc.contributor.authorHedrick, James J.
dc.contributor.authorZhan, Yuin Ong
dc.contributor.authorYi, Yan Yang
dc.contributor.authorSardon Muguruza, Haritz
dc.date.accessioned2019-02-21T19:00:32Z
dc.date.available2019-02-21T19:00:32Z
dc.date.issued2017-01-24
dc.identifier.citationLangmuir 33(8) : 1959-1968 (2017)es_ES
dc.identifier.issn0743-7463
dc.identifier.urihttp://hdl.handle.net/10810/31651
dc.description.abstractPolyurethanes (PUs) are considered ideal candidates for drug delivery applications due to their easy synthesis, excellent mechanical properties, and biodegradability. Unfortunately, methods for preparing well-defined PU nanoparticles required miniemulsion polymerization techniques with a nontrivial control of the polymerization conditions due to the inherent incompatibility of isocyanate-containing monomers and water. In this work, we report the preparation of soft PU nanoparticles in a one-pot process using interfacial polymerization that employs a non-isocyanate polymerization route that minimizes side reactions with water. Activated pentafluorophenyl dicarbonates were polymerized with diamines and/or triamines by interfacial polymerization in the presence of an anionic emulsifier, which afforded non-isocyanate polyurethane (NIPU) nanoparticles with sizes in the range of 200–300 nm. Notably, 5 wt % of emulsifier was required in combination with a trifunctional amine to achieve stable PU dispersions and avoid particle aggregation. The versatility of this polymerization process allows for incorporation of functional groups into the PU nanoparticles, such as carboxylic acids, which can encapsulate the chemotherapeutic doxorubicin through ionic interactions. Altogether, this waterborne synthetic method for functionalized NIPU soft nanoparticles holds great promise for the preparation of drug delivery nanocarriers.es_ES
dc.description.sponsorshipThe authors thank the European Commission for their financial support through the project SUSPOL-EJD 642671 and the Gobierno Vasco/Eusko Jaurlaritza (IT 999-16). Haritz Sardon gratefully acknowledges financial support from MINECO through project SUSPOL and FDI 16507. Yi Yan Yang gratefully acknowledges financial support from the Institute of Bioengineering and Nanotechnology (Biomedical Research Council and Joint Council Office, Agency for Science, Technology and Research, Singapore).es_ES
dc.language.isoenges_ES
dc.publisherACSes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/642671es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectpolyurethaneses_ES
dc.subjectnanogelses_ES
dc.subjectisocyanate freees_ES
dc.titleNon-Isocyanate Polyurethane Soft Nanoparticles Obtained by Surfactant-Assisted Interfacial Polymerizationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2017 American Chemical Societyes_ES
dc.relation.publisherversionhttps://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b04242es_ES
dc.identifier.doi10.1021/acs.langmuir.6b04242
dc.contributor.funderEuropean Commision
dc.departamentoesCiencia y tecnología de polímeroses_ES
dc.departamentoeuPolimeroen zientzia eta teknologiaes_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record