Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort
dc.contributor.author | Andiarena Villaverde, Ainara | |
dc.contributor.author | Irizar, Amaia | |
dc.contributor.author | Molinuevo, Amaia | |
dc.contributor.author | Urbieta Macazaga, Nerea | |
dc.contributor.author | Babarro Vélez, Izaro | |
dc.contributor.author | Subiza Pérez, Mikel | |
dc.contributor.author | Santa Marina Rodríguez, Loreto | |
dc.contributor.author | Ibarluzea Maurolagoitia, Jesús María | |
dc.contributor.author | Lertxundi Manterola, Aitana | |
dc.date.accessioned | 2020-03-18T18:08:26Z | |
dc.date.available | 2020-03-18T18:08:26Z | |
dc.date.issued | 2020-03-04 | |
dc.identifier.citation | International Journal of Environmental Research and Public Health 17(5) : (2020) // Article ID 1665 | es_ES |
dc.identifier.issn | 1660-4601 | |
dc.identifier.uri | http://hdl.handle.net/10810/42233 | |
dc.description.abstract | Background: Manganese (Mn) is an essential micronutrient for humans, the diet being the main source of exposure. Some epidemiological studies describe a negative association between prenatal Mn and later neuropsychological development, but results are inconsistent. The aim of this study was to explore the association between prenatal Mn exposure and neuropsychological development assessed at 4 years of age. Methods: Study subjects were 304 mother-child pairs from the Gipuzkoa cohort of the INMA (Environment and Childhood) Project. Mn was measured in newborns’ hair. Children’s neuropsychological development was assessed at 4 years of age using the McCarthy Scales of Children’s Abilities. Multivariate linear regression models were built. Stratified analysis by sex was performed. Generalized additive models were used to assess the shape of the relation. Results: The median Mn concentration in newborns’ hair was 0.42 μg/g (95% CI = 0.38, 0.46). The association between Mn levels and the neuropsychological development was not statistically significant for the general cognitive scale (β [95% CI] = 0.36 [−5.23, 5.95]), motor scale (β [95% CI] = 1.9 [−3.74, 7.55]) or any of the other outcomes. No sex-specific pattern was found. The best shape describing the relationship was linear for all the scales. Conclusion: Our results suggest that prenatal Mn concentrations measured in newborns’ hair do not affect cognitive or motor development at 4 years of age in boys or in girls at the observed Mn levels. | es_ES |
dc.description.sponsorship | This study is part of the INMA (INfancia y MedioAmbiente) project. This research was funded by the Spanish Ministry of Health (FIS-FEDER PI060867 and PI09/00090), the Council of Gipuzkoa (DFG15/009), Health Department of the Basque Government (2013111089), CIBERESP and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | hair Mn | es_ES |
dc.subject | in utero exposure | es_ES |
dc.subject | prenatal | es_ES |
dc.subject | neurodevelopment | es_ES |
dc.subject | prospective | es_ES |
dc.title | Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-03-13T13:09:37Z | |
dc.rights.holder | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1660-4601/17/5/1665 | es_ES |
dc.identifier.doi | 10.3390/ijerph17051665 | |
dc.departamentoes | Personalidad, evaluación y tratamiento psicológico | es_ES |
dc.departamentoeu | Nortasuna, balioespena eta psikologia tratamendua | es_ES |
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Except where otherwise noted, this item's license is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).