dc.contributor.author | Talamillo, Ana | |
dc.contributor.author | Ajuria, Leiore | |
dc.contributor.author | Grillo, Marco | |
dc.contributor.author | Barroso Gomila, Orhi | |
dc.contributor.author | Mayor Martínez, Ugo ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Barrio Olano, María Rosa | |
dc.date.accessioned | 2020-05-12T20:26:24Z | |
dc.date.available | 2020-05-12T20:26:24Z | |
dc.date.issued | 2020-05 | |
dc.identifier.citation | Open Biology 10(5) : (2020) // Article ID 200054 | es_ES |
dc.identifier.issn | 2046-2441 | |
dc.identifier.uri | http://hdl.handle.net/10810/43175 | |
dc.description.abstract | SUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis. Cholesterol is one of the main lipids required to preserve the correct cellular function, contributing to the composition of the plasma membrane and participating in transmembrane receptor signalling. Besides these functions, cholesterol is required for the synthesis of steroid hormones, bile acids, oxysterols and vitamin D. Cholesterol levels need to be tightly regulated: in excess, it is toxic to the cell, and the disruption of its homeostasis is associated with various disorders like atherosclerosis and cardiovascular diseases. This review focuses on the role of SUMO in the regulation of proteins involved in the metabolism of cholesterol. | es_ES |
dc.description.sponsorship | We apologize to those whose related publications could not be cited due to space limitations. We are grateful to all members of Barrio's Lab for comments and suggestions. R.B. acknowledges grant nos. BFU2017-84653-P (MINECO/AEI/FEDER/EU), SEV-2016-0644 (Severo Ochoa Excellence Program, MINECO/AEI), 765445-EU (UbiCODE Program, EU) and SAF2017-90900-REDT (UBIRed Program, MINECO/AEI). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | The Royal Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/BFU2017-84653-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SEV-2016-0644 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2017-90900-REDT | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/765445 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | SUMOylation | es_ES |
dc.subject | cholesterol homeostasis | es_ES |
dc.subject | ubiquitin-like | es_ES |
dc.title | SUMOylation in the control of cholesterol homeostasis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://royalsocietypublishing.org/doi/full/10.1098/rsob.200054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed | es_ES |
dc.identifier.doi | 10.1098/rsob.200054 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Bioquímica y biología molecular | es_ES |
dc.departamentoeu | Biokimika eta biologia molekularra | es_ES |