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dc.contributor.authorDe Pasquale, Daniele
dc.contributor.authorMarino, Attilio
dc.contributor.authorTapeinos, Christos
dc.contributor.authorPucci, Carlotta
dc.contributor.authorRocchiccioli, Silvia
dc.contributor.authorMichelucci, Elena
dc.contributor.authorFinamore, Francesco
dc.contributor.authorMcDonnell, Liam
dc.contributor.authorScarpellini, Alice
dc.contributor.authorLauciello, Simone
dc.contributor.authorPrato, Mirko
dc.contributor.authorLarrañaga Espartero, Aitor
dc.contributor.authorDrago, Filippo
dc.contributor.authorCiofani, Gianni
dc.date.accessioned2020-05-15T12:22:31Z
dc.date.available2020-05-15T12:22:31Z
dc.date.issued2020-07
dc.identifier.citationMaterials & design 192 : (2020) // Article ID 108742es_ES
dc.identifier.issn0264-1275
dc.identifier.urihttp://hdl.handle.net/10810/43233
dc.description.abstractGlioblastoma multiforme (GBM) is one of the most aggressive types of brain cancer, characterized by rapid progression, resistance to treatments, and low survival rates; the development of a targeted treatment for this disease is still today an unattained objective. Among the different strategies developed in the latest few years for the targeted delivery of nanotherapeutics, homotypic membrane-membrane recognition is one of the most promising and efficient. In this work, we present an innovative drug-loaded nanocarrier with improved targeting properties based on the homotypic recognition of GBM cells. The developed nanoplatform consists of boron nitride nanotubes (BNNTs) loaded with doxorubicin (Dox) and coated with cell membranes (CM) extracted from GBM cells (Dox-CM-BNNTs). We demonstrated as Dox-CM-BNNTs are able to specifically target and kill GBM cells in vitro, leaving unaffected healthy brain cells, upon successful crossing an in vitro blood-brain barrier model. The excellent targeting performances of the nanoplatform can be ascribed to the protein component of the membrane coating, and proteomic analysis of differently expressed membrane proteins present on the CM of GBM cells and of healthy astrocytes allowed the identification of potential candidates involved in the process of homotypic cancer cell recognition.es_ES
dc.description.sponsorshipThis project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement N°709613, SLaMM).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/709613es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectboron nitride nanotubeses_ES
dc.subjectcell-membrane coatinges_ES
dc.subjectglioblastoma multiformees_ES
dc.subjecthomotypic targetinges_ES
dc.titleHomotypic targeting and drug delivery in glioblastoma cells through cell membrane-coated boron nitride nanotubeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Contents lists available atScienceDirectMaterials and Designjournal homepage:www.elsevier.com/locate/matdeses_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0264127520302768?via%3Dihubes_ES
dc.identifier.doi10.1016/j.matdes.2020.108742
dc.contributor.funderEuropean Commission
dc.departamentoesIngeniería Minera y Metalúrgica y Ciencia de los Materialeses_ES
dc.departamentoeuMeatze eta metalurgia ingeniaritza materialen zientziaes_ES


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2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Contents lists available atScienceDirectMaterials and Designjournal homepage:www.elsevier.com/locate/matdes
Except where otherwise noted, this item's license is described as 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Contents lists available atScienceDirectMaterials and Designjournal homepage:www.elsevier.com/locate/matdes