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The role of SUMOylation during development

dc.contributor.authorTalamillo, Ana
dc.contributor.authorBarroso Gomila, Orhi
dc.contributor.authorGiordano, Immacolata
dc.contributor.authorAjuria, Leiore
dc.contributor.authorGrillo, Marco
dc.contributor.authorMayor Martínez, Ugo ORCID
dc.contributor.authorBarrio Olano, María Rosa
dc.date.accessioned2020-06-08T12:53:51Z
dc.date.available2020-06-08T12:53:51Z
dc.date.issued2020-04
dc.identifier.citationBiochemical Society Transactions 48 : 463–478 (2020)es_ES
dc.identifier.issn0300-5127
dc.identifier.issn1470-8752
dc.identifier.urihttp://hdl.handle.net/10810/43857
dc.description.abstractDuring the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a `molecular glue' by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals.es_ES
dc.description.sponsorshipWe apologize to those whose related publication could not be cited due to space limitations. We are grateful to all members of Barrio's Lab for comments and suggestions. R.B. acknowledges grants BFU2017-84653-P (MINECO/AEI/FEDER/EU), SEV-2016-0644 (Severo Ochoa Excellence Program, MINECO/AEI), 765445-EU (UbiCODE Program, EU), SAF2017-90900-REDT (UBIRed Program, MINECO/AEI).es_ES
dc.language.isoenges_ES
dc.publisherPortland Presses_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/BFU2017-84653-Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SEV-2016-0644es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/765445es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectSUMO e3 ligasees_ES
dc.subjectconjugating enzymees_ES
dc.subjectisopeptidase senp3es_ES
dc.subjectandrogen receptores_ES
dc.subjectprotease 2es_ES
dc.subjectin-vivoes_ES
dc.subjectgene cell-cycle progressiones_ES
dc.subjectbox factor tbx-2es_ES
dc.subjectchromosome congressiones_ES
dc.titleThe role of SUMOylation during developmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.relation.publisherversionhttps://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST20190390es_ES
dc.identifier.doi10.1042/BST20190390
dc.contributor.funderEuropean Commission
dc.departamentoesBioquímica y biología moleculares_ES
dc.departamentoeuBiokimika eta biologia molekularraes_ES


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This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
Except where otherwise noted, this item's license is described as This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).